Progress in Iron Research

By: Chaim Hershko (Editor)

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Based on presentations at two conferences held in April and May 1993, respectively (the first a clinical meeting, the second a forum designed primarily for basic scientists), this volume offers a comprehensive, state-of-the-art review on most aspects of iron metabolism. Chapters on the biophysical a

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Mechanism of Fe(II) Oxidation and Core Formation in Ferritin	p. 1
Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin	p. 13
Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins	p. 23
The Transferrin Receptor and the Release of Iron from Transferrin	p. 31
The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages	p. 41
Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition	p. 51
Mechanism of Production of the Serum Transferrin Receptor	p. 61
Iron Absorption and Cellular Uptake of Iron	p. 69
Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe	p. 81
Cellular Responses to Iron and Iron Compounds	p. 91
The Structure and Function of Iron Regulatory Factor	p. 101
Structure and Function of IREs, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase	p. 111
Translational Control by Iron-Responsive Elements	p. 119
The Role of Cytokines in the Regulation of Ferritin Expression	p. 127
Stimulation of IRE-BP Activity of IREF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase	p. 133
Reciprocal Modulation of Aconitase Activity and RNA-binding Activity of Iron Regulatory Factor by Nitric Oxide	p. 141
A New Look at Ferritin Metabolism	p. 149
Bacterioferritin: A Hemoprotein Member of the Ferritin Family	p. 157
Intracellular Iron	p. 165
Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation	p. 173
Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells	p. 189
Differential Effects of Iron and Iron Carrier on Hematopoietic Cell Differentiation and Human ADA Gene Transfer	p. 199
A Hemin-Inducible Enhancer Lies 4.5 Kb Upstream of the Mouse Ferritin H Subunit Gene	p. 211
Iron Deficiency: The Global Perspective	p. 219
Iron Regulation in the Brain at the Cell and Molecular Level	p. 229
Pathophysiology of Iron Toxicity	p. 239
Morphologic Observations in Iron Overload: An Update	p. 255
Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells	p. 267
Iron Overload and the Biliary Route	p. 277
Changing Concepts of Haemochromatosis	p. 285
Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis	p. 293
The Morbidity of Hemochromatosis Among Clinically Unselected Homozygotes: Preliminary Report	p. 303
Genetics of Haemochromatosis	p. 309
Localization of Seven New Genes Around the HLA-A Locus	p. 319
Searching for the Hemochromatosis Grail	p. 331
Iron Chelator Design	p. 343
Results from a Phase I Clinical Trial of HBED	p. 351
Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds	p. 361
Iron Chelation Therapy for Malaria	p. 371
The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells	p. 385
Index	p. 399
Table of Contents provided by Blackwell. All Rights Reserved.

Progress in Iron Research

At a Glance

Hardcover

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