Process Chemistry in the Pharmaceutical Industry

Overview

Process Chemistry in the Pharmaceutical Industry: An Overview, Kumar G. Gadamasetti

Strategy

Process Research and Development Strategy for Accelerated Projects, Christopher M. Cimarusti

Case Studies

A Practical Synthesis of Ifetroban Sodium, Richard H. Mueller
Synthesis of 5-Lipoxygenase Inhibitors, Ivan Lantos and Richard Matsuoka
Chemistry of Vitamin D: A Challenging Field for Process Research, Masami Okabe
A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator, Hans-J¼rgen Federsel and Edib Jakupovic
Ontazolast: The Evolution of a Process, Vittorio Farina, Karl Grozinger, Hermann M¼ller-B¶tticher and Gregory P. Roth
Dilevalol Hydrochloride: Development of a Commercial Process, Derek Walker
Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist, Michael J. Martinelli and David L. Varie
Process Research and Development of CGS 19755, an NMDA Antagonist, Peter Giannousis, John Carlson and Marius Leimer
Route Evaluation for the Production of (R)-Levoprotiline, H. U. Blaser, R. Gamboni, B. Pugin, G. Rihs, G. Sedelmeier, E. Schaub, E. Schmidt, B. Schmitz, F. Spindler and Hj. Wetter
The Process Research and Development of DuPont Merckâs Cyclic Urea Diols, A New Class of HIV Protease Inhibitors, Pat N. Confalone and Robert E. Waltermire
Practical Enantio- and Diastereo-selective Processes for Azetidinones, T. K. Thiruvengadam, Anantha R. Sudhakar, and Guangzhong Wu
Synthesis of the Common Lactone Moiety of HMG-CoA Reductase Inhibitors, Ian M. McFarlane, Christopher G. Newton and Philippe Pitchen

Enzymatic Intervention and Phase Transfer Catalysis

Chemistry, Biocatalysis and Engineering: An Interdisciplinary Approach to the Manufacture of the Benzodiazepine Drug Candidate LY 300164, Benjamin A. Anderson, Marvin M. Hansen, Jeffrey T. Vicenzi and Milton J. Zmijewski
Benefits and Challenges of Applying Phase-Transfer Catalysis Technology in the Pharmaceutical Industry, Marc E. Halpern

Asymmetric Synthesis and Enantioselectivity

Enantioselective Synthesis: The Optimum Process, John J. Partridge and Brian L. Bray
Practical Catalysts for Asymmetric Synthesis: Ligands from Natural Sugars for Rh-Catalyzed Asymmetric Synthesis of D- and L- Amino Acids, Timothy A. Ayers and T. V. Rajan Babu
Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis, Chris H. Senanayake and Eric N. Jacobsen

Drug Substance Final Form and Process Safety

Chemical Development of the Drug Substance Solid Form, Michael D. Thompson and Jean-Ren© Authelin
The Basic Principles of Thermal Process Safety: Towards a Better Communication Between Safety Experts and Process Chemists, Wilfried Hoffmann

Design of Experiments and Automation

Using Factorial Experiments in the Development of Process Chemistry, Daniel R. Pilipauskas
Laboratory Automation in Chemical Development, Martin R. Owen and Sheila H. Dewitt