Phenotypic Switching

Implications in Biology and Medicine

By: Jolly, Levine, Kulkarni, Nanjundiah

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Paperback | 8 June 2020 | Edition Number 1

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762 Pages

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23.5 x 19.05 x 3.0

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Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more.

This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast.

Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity
Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies
Features a diverse range of chapter contributions from international leaders in the field

Industry Reviews

"This is a very high-quality book that targets a developing area of biological research and fully fleshes it out thanks to excellent authorship. The volume is intended for a fairly narrow and select audience. It provides a comprehensive overview of the field as it stands today." --Doody

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