Pharmaceutical Biocatalysis

Name: Pharmaceutical Biocatalysis
Brand: Pan Stanford Publishing Pte Ltd
Price: 682.75 AUD
Availability: BackOrder

Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

By: Peter Grunwald (Editor)

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Hardcover | 20 December 2019 | Edition Number 1

At a Glance

Hardcover
862 Pages

Dimensions(cm)
22.9 x 15.2 x 4.45

Hardcover

RRP $809.00

$682.75

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This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

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