Oxidative Stress

Clinical & Biomedical Implications

By: Bashir M Matata (Editor), Maqsood M Elahi (Editor)

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Hardcover | 1 September 2007

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330 Pages

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26.3 x 18.6 x 2.7

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There is an emerging concept that nitric oxide (NO), its derivatives and reactive oxygen intermediates (ROS) are the major determinants of the involvement of oxidant stress that contributes to the control of physiological cell signalling processes, blood flow regulation and pathological hypoxia. There is recent published evidence for additional functions of these oxygen metabolites in cardiac gene expression; functions that include the modulation of the cytokine response of lymphocytes and the regulation of immune cell apoptosis as well as immuno-deviating effects. In vitro and in vivo experimental models investigating the biological nature of ROS have shown that there is a concentration dependent effect of NO and that differences in cell sensitivity to NO may have an impact upon the degree of immune or inflammatory state. Disturbances in NO bio-availability leads to loss of cardioprotective actions within biological systems and in some cases may even increase oxidative stress and disease progression. Hence, considerable interest in identifying the mechanisms involved in their generation and implications have spurted in the hope that inhibition strategies can be developed either bio-materially or pharmacologically. This book brings together the emerging biological concepts of oxidative stress and its connotation in the pathogenesis of various inflammatory processes in biological systems.

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Non-Fiction Science Biology, Life Sciences Biochemistry Medicine Pre-Clinical Medicine & Basic Sciences Physiology Medicine in General Medical Equipment & Techniques Medical Research

Preface	p. vii
Ethnic Diversity and Oxidative Stress in Health and Disease	p. 1
Sources of Reactive Oxidants Species in Biology and Disease	p. 23
The Emerging Role of Reactive Oxidant Species on Regulating Pathways of Biomaterials Biocompatibility	p. 39
Steady-State Titration with H2O2: Regulation of Plasma Membrane Permeability and of NF-kB Activation by H2O2	p. 59
Reactive Oxygen Species as a Mediator of Cardioprotection	p. 69
Pyruvate: A Physiologic Energy Substrate and Antioxidant for Cardiopulmonary Bypass	p. 85
Redox Regulation of Cell Signaling	p. 103
Oxidative Stress: Dysregulation or Bad Setpoint? Interactions with Basal NO	p. 133
The Biological Significance of the Nitric Oxide-Dependent Mitochondrial Biogenesis	p. 145
S-Nitrosothiols in Disease	p. 157
Flavonoids, Endothelial Function, and Cardiovascular Disease	p. 171
NO Regulatory Networks in Bacteria Focusing on Pathogenic Bacteria	p. 183
Endogenous Regulation of Nitric Oxide Synthase Activity and Free Radical Generation	p. 203
Nitric Oxide Cell Signaling in Cellular Processes	p. 227
The Role of Nitric Oxide in Cardiovascular Diseases	p. 245
Airways Inflammation and Reactive Oxygen/Nitrogen Species in Pulmonary Hypertension	p. 259
Peroxynitrite and Nitrosative Stress in Heart Failure: Role of Matrix Metalloproteinases (MMPS) and Poly(ADP)-Ribose Polymerase (PARP)	p. 277
Reactive Oxidant Species and Emerging Therapies in Clinical Medicine	p. 291
Index	p. 307
Table of Contents provided by Ingram. All Rights Reserved.

Oxidative Stress

Clinical & Biomedical Implications

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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