Nucleic Acid-Based Nanomaterials

Preface xi

1 Introductions of Nucleic Acid-Based Nanomaterials 1
Shaojingya Gao and Yunfeng Lin

1.1 History of DNA-Based Nanomaterials - Design and Construction 3

2 The Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials 15
Xueping Xie

2.1 Introduction 15

2.2 Methods to Improve Stability 16

2.3 Conclusion and Recommendations 26

3 Framework Nucleic Acid-Based Nanomaterials: A Promising Vehicle for Small Molecular Cargos 37
Yanjing Li

3.1 Basis of FNAs as Potential Drug Carriers 38

3.2 Small-molecule Cargos 41

3.3 Merits of FNA Delivery Systems in Biomedical Application 46

3.4 Conclusions and Prospects 52

4 The Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Mitochondrial Dysfunction 61
Lan Yao and Tao Zhang

4.1 Introduction 61

4.2 Treatment Mechanisms in Mitochondrial Dysfunction 61

4.3 Nucleic Acid Nanomaterial-Based Delivery System in Mitochondrial Treatment 65

4.4 Challenges and Prospectives 71

5 Regeneration of Bone-Related Diseases by Nucleic Acid-Based Nanomaterials: Perspectives from Tissue Regeneration and Molecular Medicine 81
Xiaoru Shao

5.1 Introduction 81

5.2 The Development Process of Functional Nucleic Acid 82

5.3 Nucleic Acid-Based Functional Nanomaterials 84

5.4 Multiple Roles of Nucleic Acid-Based Functional Nanomaterials in Bone Tissue Repair and Regeneration 89

5.5 Conclusion and Perspectives 94

6 In Situ Fluorescence Imaging and Biotherapy of Tumor Based on Hybridization Chain Reaction 101
Ye Chen, Songhang Li, and Taoran Tian

6.1 Hybridization Chain Reaction 102

6.2 Nucleic Acid Detection 102

6.3 Protein Detection 107

6.4 Multiple Target Detection 109

6.5 HCR-Based Assembly Nanoplatforms 113

6.6 HCR-Based Tumor Biotherapy 115

6.7 Conclusion 116

7 Application and Prospects of Framework Nucleic Acid-Based Nanomaterials in Tumor Therapy 123
Tianyu Chen and Xiaoxiao Cai

7.1 Development of Nucleic Acid Nanomaterials 124

7.2 Properties and Applications of Nucleic Acid Nanomaterials 125

7.3 Conclusion 133

8 Application of Framework Nucleic Acid-Based Nanomaterials in the Treatment of Endocrine and Metabolic Diseases 139
Jingang Xiao

8.1 Endocrine and Metabolic Diseases 139

8.2 Nucleic Acid Nanomaterials 141

8.3 Nucleic Acid and Drugs 141

8.4 Nucleic Acid Nanomaterials for Endocrine and Metabolic Diseases 144

8.5 Conclusion and Outlook 149

9 The Antibacterial Applications of Framework Nucleic Acid-Based Nanomaterials: Current Progress and Further Perspectives 161
Zhiqiang Liu and Yue Sun

9.1 Some Advantages of DNA Nanostructures in the Antibacterial Field 163

9.2 Application of 2D Nanostructures in the Antibacterial Field 164

9.3 Application of 3D DNA Nanostructures in the Antibacterial Field 166

9.4 Application of DNA Hydrogel Nanostructures in the Antibacterial Field 170

9.5 Challenges and Further Perspectives 172

10 Framework Nucleic Acid Nanomaterial-Based Therapy for Osteoarthritis: Progress and Prospects 181
Yangxue Yao, Hongxiao Huang, and Sirong Shi

10.1 Introduction 181

10.2 Pathology of OA 181

10.3 Risk Factors of OA 183

10.4 Challenges for OA Therapy 183

10.5 Nucleic Acid Nanomaterial-Based Therapy for OA 184

10.6 Conclusion and Prospects 194

References 195

Index 205