| Preface | p. xi |
| Endosomes Come of Age | p. 1 |
| The Discovery of Endosomes | p. 2 |
| Endosome Subpopulations | p. 4 |
| Endosome Maturation | p. 5 |
| Acidification | p. 6 |
| Sorting Stations at the Crossroads of Membrane Traffic | p. 8 |
| Endosomes in Specialized Cells | p. 9 |
| Lipid Membrane Domains in Endosomes | p. 14 |
| Mophologically-Visible Domains | p. 15 |
| Lipid Distribution | p. 15 |
| Functionally Different Membrane Domains | p. 16 |
| LBPA and Alix/ALP1 | p. 17 |
| Intra-Luminal Traffic | p. 18 |
| Rab Domains on Endosomes | p. 23 |
| Rab Proteins as Determinants of Organelle Identity | p. 24 |
| Rab Proteins as Organizers of Membrane Domains | p. 25 |
| Molecular Assembly of a Rab Domain | p. 26 |
| Functional Coordination between Components of the Rab5 Domain | p. 29 |
| Dynamic Coupling between Rab Domains | p. 30 |
| Future Prospects | p. 31 |
| Synaptic Endosomes | p. 36 |
| Membrane Trafficking Events at Synapses | p. 36 |
| Presynaptic Endosomal Compartments | p. 38 |
| Endosomes in Postsynaptic Receptor Trafficking | p. 42 |
| Endosome Fusion | p. 50 |
| Introduction: Fusion Steps in the Endocytotic Pathway | p. 50 |
| Tethering and Docking | p. 52 |
| SNARE-Proteins: Central Players in Membrane Fusion | p. 53 |
| SM-Proteins: Essential but Still Enigmatic | p. 56 |
| Late Steps in the Fusion Pathway and Fusion Catalysis | p. 56 |
| Clathrin Adaptor Proteins in Cargo Endocytosis | p. 62 |
| Sorting Signals for Selective Internalization | p. 62 |
| Clathrin-Mediated Endocytosis | p. 63 |
| The AP-2 Adaptor Complex | p. 64 |
| Diversity in Cargo Recognition Events | p. 66 |
| Clathrin-Associated Sorting Proteins (CLASPs), the Alternate Adaptors | p. 67 |
| PTB Domain CLASPs and FXNPXY Signal Endocytosis | p. 68 |
| ENTH/ANTH-Domain Containing CLASPs | p. 69 |
| Protein Sorting in Endosomes | p. 76 |
| Endosomes as Sorting Stations in Intracellular Membrane Trafficking | p. 76 |
| Sorting to the Recycling Route | p. 77 |
| Sorting to the Degradative Pathway | p. 79 |
| Sorting to the Biosynthetic Pathway | p. 83 |
| Signaling from Internalized Receptors | p. 89 |
| RTKS: Temporal and Spatial Regulation of Signaling | p. 90 |
| Notch: Endocytosis is Required for Signaling | p. 92 |
| Different Endocytic Route Different Signaling: The TGF-[Beta]R Paradigm | p. 94 |
| GPCR and [Beta]-Arrestin: Signaling from the Endosomes | p. 95 |
| Endocytosis of Receptor Tyrosine Kinases: Implications for Signal Transduction by Growth Factors | p. 101 |
| Common Molecular Mechanisms in Receptor Endocytosis: Curvature Sensing and Post-Translational Protein Modifications | p. 103 |
| The Journey of RTKs to the Lysosome | p. 104 |
| The Interface of Receptor Trafficking and Signaling | p. 112 |
| Ligand-Independent Pathways of RTK Endocytosis | p. 113 |
| Perspectives | p. 113 |
| Endocytic Trafficking and Human Diseases | p. 119 |
| Defects in Protein-Sorting Machinery | p. 119 |
| Defects in Lysosomal Biogenesis | p. 122 |
| Defects in Function of Endosomal Rabs | p. 123 |
| Defects in Lipid Trafficking | p. 126 |
| Autoimmune Diseases | p. 127 |
| Endosomes-Key Components in Viral Entry and Replication | p. 132 |
| Virus Entry | p. 132 |
| Virus Endocytosis | p. 134 |
| Caveosomes-Parallel Endosome-like Organelles | p. 134 |
| Endosome Function in Virus Entry | p. 135 |
| Endosomes in Virus Assembly | p. 136 |
| Endosomes in Antigen Presentation | p. 139 |
| Viral Modulation of Endosome Trafficking | p. 140 |
| Toxins in the Endosomes | p. 145 |
| Different Portals of Entry into the Cell | p. 146 |
| Early Endosomes: Toxin Translocation Site or Transit Area | p. 147 |
| Late Endosomes: Who Can Make It That Far and What For? | p. 148 |
| Index | p. 153 |
| Table of Contents provided by Ingram. All Rights Reserved. |