Molecular Biology Intelligence Unit

By: Eugene V. Koonin (Editor), Yuri Wolf (Editor), Georgy Karev (Editor)

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Hardcover | 17 March 2006

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Hardcover
280 Pages

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22.86 x 15.88 x 1.91

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Power Laws, Scale-free Networks and Genome Biology deals with crucial aspects of the theoretical foundations of systems biology, namely power law distributions and scale-free networks which have emerged as the hallmarks of biological organization in the post-genomic era. The chapters in the book not only describe the interesting mathematical properties of biological networks but moves beyond phenomenology, toward models of evolution capable of explaining the emergence of these features. The collection of chapters, contributed by both physicists and biologists, strives to address the problems in this field in a rigorous but not excessively mathematical manner and to represent different viewpoints, which is crucial in this emerging discipline. Each chapter includes, in addition to technical descriptions of properties of biological networks and evolutionary models, a more general and accessible introduction to the respective problems. Most chapters emphasize the potential of theoretical systems biology for discovery of new biological phenomena.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Molecular Biology Physics Applied Physics Biophysics Cellular Biology Biochemistry Reference, Information & Interdisciplinary Subjects

Research & Information Information theory Cybernetics & Systems Theory

Power laws in biological networks	p. 1
Graphical analysis of biocomplex networks and transport phenomena	p. 12
Large-scale topological properties of molecular networks	p. 25
The connectivity of large genetic networks : design, history, or mere chemistry?	p. 40
The drosophila protein interaction network may be neither power-law nor scale-free	p. 53
Birth and death models of genome evolution	p. 65
Scale-free evolution : from proteins to organisms	p. 86
Gene regulatory networks	p. 106
Power law correlations in DNA sequences	p. 123
Analytical evolutionary model for protein fold occurrence in genomes, accounting for the effects of gene duplication, deletion, acquisition and selective pressure	p. 165
The protein universes : some informatic issues in protein classification	p. 194
The role of computation in complex regulatory networks	p. 206
Neutrality and selection in the evolution of gene families	p. 226
Scaling laws in the functional content of genomes : fundamental constants of evolution?	p. 236
Table of Contents provided by Blackwell. All Rights Reserved.

Molecular Biology Intelligence Unit

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Hardcover

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