Misbehaving Proteins

Protein (Mis)Folding, Aggregation, and Stability

By: Regina Murphy (Editor), Amos Tsai (Editor)

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Hardcover | 24 May 2006

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364 Pages

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23.39 x 15.6 x 2.06

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Misfoldedaggregatedproteinoncewasconsideredasinterestingasyesterday'strash--a bothersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterday's trash has become today's focus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimer's disease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently. Misbehaving Proteins: Protein (Mis)folding, Aggregation, and Stability differs from theseotherrecenteffortsinitsemphasisonfundamentalcomputationalandexperimental studies and in its linkage of disparate consequences of protein misfolding (e.g., from clinical manifestations to manufacturing headaches) to their common causes.

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Non-Fiction Science Biology, Life Sciences Biochemistry Proteins Chemistry Analytical Chemistry Engineering & Technology Biochemical Engineering Biotechnology Molecular Biology Industrial Chemistry & Manufacturing Technologies

Industrial Chemistry

Introduction
Protein Folding, Misfolding, Stability, and Aggregation: An Overview	p. 3
Mathematical Models and Computational Methods
Nonnative Protein Aggregation: Pathways, Kinetics, and Stability Prediction	p. 17
Simulations of Protein Aggregation: A Review	p. 47
Experimental Methods
Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry	p. 81
Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development	p. 99
Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales	p. 125
Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation	p. 147
X-Ray Diffraction for Characterizing Structure in Protein Aggregates	p. 167
Glass Dynamics and the Preservation of Proteins	p. 193
Fundamental Studies in Model Systems
Folding and Misfolding as a Function of Polypeptide Chain Elongation: Conformational Trends and Implications for Intracellular Events	p. 217
Determinants of Protein Folding and Aggregation in P22 Tailspike Protein	p. 247
Factors Affecting the Fibrillation of [alpha]-Synuclein, a Natively Unfolded Protein	p. 265
Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation	p. 287
Protein Product Development
Self-Association of Therapeutic Proteins: Implications for Product Development	p. 313
Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation: Role of Altered Conformation in Irreversible Precipitation	p. 331
Index	p. 351
Table of Contents provided by Ingram. All Rights Reserved.

Misbehaving Proteins

Protein (Mis)Folding, Aggregation, and Stability

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Hardcover

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