Part 1: Minimum Genome Factory Chapter 1: E.coli (Dr. Hideo Mori, Kyowa Hakko Bio co.).-Chapter 2: B.subtilis (Kao Co.).-Chapter 3: Schizosaccharomyces pombe (Asahi Glass Co.) Part 2: Large Scale Genome Manipulation.-Chapter 4: Synthetic Biology: design a genome with long-size DNA (Dr. M. Itaya, Keio Univ.).-Chapter 5: Development and application of novel technology on Saccharomyces cerevisiae (Dr. S. Harashima, Osaka Univ.).-Chapter 6: Genome design of Actinomycetes (Dr. H. Ikeda, Kitasato Univ.) Part 3: Application of Omics information and Creation of mutant library.-Chapter 7: Application methodology of whole omics information (Dr. M. Machida, AIST).-Chapter 8: Aspergillus oryzae (Dr. Y. Koyama, Kokkoman co.).-Chapter 9: E.coli (Dr. Hirotada Mori, Nara Fronteer Tec. Univ.).-Chapter 10: S.pombe (Dr. K. Takekawa, Kyoshu Univ.).-Chapter 11: Corynebacterium glutamicum (Dr. M. Ikeda, Shinshu Univ.) Part 4: Application of novel technology of production.-Chapter 12: Fine chemical synthesis by complex enzyme system (Dr. Y. Yasohara, Kaneka co.).-Chapter 13: Application of solvent resistant microorganisms (Dr. A. Mastuyama, Dicel co.).-Chapter 14: Simulation of CYP450 Reaction (Dr. H. Fukunishi, NEC co.).-Chapter 15: Improved protein excretion by cell surface engineering (Dr. J. Sekiguchi, Shinshu Univ.).-Chapter 16: Protein excretion production by Aspergillus oryzae (Dr. K. Gomi, Tohoku Univ.).-Chapter 17: Glutamate Production (Dr. H. Yasueda, Ajinomoto co.) Part 5: Pharmaceuticals.-Chapter 18: Microbioal Hormons induction of 2nd metabolite production in Actinomycetes (Dr. Y. Onishi, Tokyo Univ.).-Chapter 19: Enzymatic production of designed peptide (Dr. K. Kino, Waseda Univ.) Part 6: Functional Foods.-Chapter 20: Microbiological Production of unsaturated lipids (Dr. J. Ogawa, Kyoto Univ.).-Chapter 21: Enzymatic production of Oligosaccharides (Dr. T. Kuroiwa, Tokyo Metropolitan Univ.) Part 7: Cosmetics.-Chapter 22: Low materials from Lactic acid fermentation (Dr. N. Izawa, Yakuruto co.).-Chapter 23: Tyrosinase and its inhibitors (Dr. M. Sugiyama or Y. Matoba, Hiroshima Univ.) Part 8: Energy.-Chapter 24: Biorefinary by C.glutamicum (Dr. H. Yukawa, RITE).-Chapter 25: Hydrogen production by photosynthetic bacteria (Dr. I. Wakayama, INPEX).-Chapter 26: Environmental cleaning and energy re-cycle by anaerobic organisms (Dr. N. Nishio, Hiroshima Univ.)