| Preface | |
| Electron Crystallography of Membrane Proteins | p. 1 |
| High-Resolution Electron Microscopy of Membrane Proteins | p. 11 |
| Distinguishing Transmembrane Helices from Peripheral Helices by Circular Dichroism | p. 17 |
| High-Resolution NMR of Membrane Proteins: the Example of Bacteriorhodopsin | p. 39 |
| Molecular Dynamics Simulations of Bacteriorhodopsin | p. 47 |
| Dynamics of Bacteriorhodopsin Studied by Neutron Scattering : Effects of the Environment, Softness and Structure | p. 61 |
| What do Neutrons, X-Ray Synchrotron Radiation, Optical pH-Indicators, and Mutagenesis tell us about the Light-Driven Proton Pump Bacteriorhodopsin? | p. 69 |
| From Time-Resolved Difference Spectra to Kinetics, Mechanism, and Thermodynamics in the Bacteriorhodopsin Photocycle | p. 85 |
| Arginine 175 is Part of an Anion Binding Site in Bacteriorhodopsin | p. 97 |
| Electrostatic Calculations of the pKa's of Ionizable Groups in Bacteriorhodopsin | p. 107 |
| Dimerization of Glycophorin A Transmembrane Helices: Mutagenesis and Modeling | p. 115 |
| The Nicotinic Acetylcholine Receptor, a Model of Ligand-Gated Ion Channels: Investigation of its Functional Organization by Protein Chemistry and Site-Directed Mutagenesis | p. 127 |
| Molecular Evolution of the Binding Site of the Nicotinic Acetylcholine Receptor | p. 147 |
| 3-D Structure of Acetylcholinesterase and Complexes of it with Anticholinesterase Agents | p. 161 |
| Modelling and Mutagenesis of Butyrylcholinesterase Based on the X-Ray Structure of Acetylcholinesterase | p. 177 |
| The Nicotinic Acetylcholine Receptor and its Lipid Microenvironment | p. 185 |
| A Correlation Between Patch Clamp and Fluorescence Anisotropy Experiments to Study Alterations on the Acethylcholine Channel Induced by Cholesterol Enrichment in Chick Myocytes | p. 199 |
| Interaction of the Nicotinic Acetylcholine Receptor with Ligands and Membrane Lipids Studied by Fourier-Transform Infrared Spectroscopy and Photoaffinity Labeling | p. 213 |
| On the Complexation of the Methylammonium Ion by Aromatic Side Chains of Proteins | p. 229 |
| The Inhibitory Glycine Receptor: Structure-Function Studies on a Neuronal Chloride Channel | p. 233 |
| Determinants of Ligand Binding to the Inhibitory Glycine Receptor | p. 241 |
| Channel Proteins: from Anatomy to Design | p. 249 |
| Linking Permeation Behavior and Structure of Ion Channels with a Microscopic Model | p. 269 |
| Molecular Structure-Function Relations in Voltage-Gated Ion Channels of Excitable Membranes | p. 279 |
| A Novel Model for Saturation of Ion Conductivity in Transmembrane Channels | p. 297 |
| Computational Approaches to Understanding the Ion Channel-Lipid System | p. 315 |
| A Minimal Model of Ion Channels: Polyamino Acids in Liposomes | p. 339 |
| Structure and Dynamics of Melittin in Solution and Membranes from Amide Hydrogen Exchange Analysis | p. 357 |
| Computer Modelling of Ion Binding Sites in Proteins | p. 367 |
| Sec-Dependent and Sec-Independent Mechanisms of Protein Insertion into Bacterial Membranes | p. 383 |
| Puncturing Cell Membranes: Comparison of Colicin A and Aerolysin | p. 393 |
| Structure-Function Relationships in the Membrane Channel Porin as Based on a 1.8 A Resolution Crystal Structure | p. 403 |
| Molecular Mechanism of Action of Pore-Forming Colicins and of their Immunity Proteins | p. 413 |
| Preliminary Structural Studies of Photosystem 1 | p. 427 |
| Problems and Progress in Computational Approaches to the Molecular Basis of Recognition | p. 443 |
| Assembly of Escherichia Coli Inner Membrane Proteins: Sec-Dependent and Sec-Independent Membrane Insertion | p. 449 |
| Molecular Dynamics Simulations of Phospholipid Membranes and their Interaction with Phospholipase | p. 457 |
| Electron Transfer in Bacterial Photosynthetic Reaction Centers | p. 471 |
| Proton Transfer Pathways in Photosynthetic Reaction Centers Studied by Site-Directed Mutagenesis | p. 481 |
| Index | p. 497 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
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