Medical Intelligence Unit (Unnumbered)

By: Christopher G. Janson, Matthew J. During

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Hardcover | 2 February 2006

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Hardcover
296 Pages

Dimensions(cm)
22.86 x 15.88 x 1.91

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This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.

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The many faces of PNA	p. 3
Modulation of nucleic acid information processing by PNAs : potential use in anti-viral therapeutics	p. 18
Targeted gene delivery : the role of peptide nucleic acid	p. 30
Imaging gene expression in the brain with peptide nucleic acid (PNA) antisense radiopharmaceuticals and drug targeting technology	p. 38
Receptor-specific targeting with complementary peptide nucleic acids conjugated to peptide analogs and radionuclides	p. 61
Morpholinos and PNAs compared	p. 89
Chemistry of locked nucleic acids (LNA) : design, synthesis and bio-physical properties	p. 114
Recent applications of RNA interference (RNAi) in mammalian systems	p. 133
Peptide nucleic acids as epigenetic inhibitors of HIV-1	p. 151
Therapeutic uses of peptide nucleic acids (PNA) in oncology	p. 171
PNAs as novel cancer therapeutics	p. 181
Medicinal chemistry of plasmid DNA with peptide nucleic acids : a new strategy for gene therapy	p. 195
Locked nucleic acids (LNA) and medical applications	p. 212
Peptide nucleic acids as agents to modify target gene expression and function	p. 223
Peptide nucleic acids : cellular delivery and recognition of DNA and RNA targets	p. 236
The use of PNAs and their derivatives in mitochondrial gene therapy	p. 243
Gene silencing through RNA interference : potential for therapeutics and functional genomics	p. 252
Transcriptional activation of human CREB gene promoter using Bis-PNA (peptide nucleic acid)	p. 265
Table of Contents provided by Blackwell. All Rights Reserved.

Medical Intelligence Unit (Unnumbered)

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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