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Methods in Molecular Medicine

By: Timothy Illidge, Tim Illidge (Editor), Peter W. M. Johnson (Editor)

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Hardcover | 17 May 2005

At a Glance

Hardcover
372 Pages

Dimensions(cm)
15.24 x 23.5 x 2.54

Hardcover

$249.00

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A cutting-edge collection of readily reproducible molecular techniques to better understand, classify, and treat lymphoma. Among the highlights are methods to use immunoglobulin gene rearrangements as markers of clonality, to exploit patterns of somatic mutation in the variable regions to indicate at which stage transformation occurred, and to apply gene arrays to the question of biological heterogeneity in morphologically similar diseases. Research methodologies that are highly likely to become routine practice in the future, such as DNA microarray and immunoglobulin V-gene rearrangements, and measurement of minimal disease, are included. There are also molecular techniques for providing for producing novel therapeutics, such as a DNA vaccine with patient-specific sequences derived from the lymphoma in question.

Industry Reviews

"Offers(s) a diverse collection of readily reproducible techniques for the molecular diagnosis and prognostic evaluation of lymphomas..." - Clinical Laboratory International

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You Can Find This Book In

Non-Fiction Medicine Clinical & Internal Medicine Diseases & Disorders Immunology Oncology Pre-Clinical Medicine & Basic Sciences

Preface	p. v
List of Contributors	p. xi
Purification of Primary Malignant B-Cells and Immunoblot Analysis of Bcl-2 Family Proteins	p. 1
Molecular Diagnosis of Lymphoma: Outcome Prediction by Gene Expression Profiling in Diffuse Large B-Cell Lymphoma	p. 15
Demonstration of a Germinal Center Immunophenotype in Lymphomas by Immunocytochemistry and Flow Cytometry	p. 65
Karyotyping Lymph Node Biopsies in Non-Hodgkin's Lymphoma	p. 93
Identification of Lymphoma-Associated Antigens Using SEREX	p. 109
Determining Mutational Status of Immunoglobulin V Genes in Chronic Lymphocytic Leukemia: A Useful Prognostic Indicator	p. 129
Idiotype Gene Rescue in Follicular Lymphoma	p. 145
Immunoglobulin Gene Mutation Patterns and Heterogeneity of Marginal Zone Lymphoma	p. 173
T-Cell Receptor Molecular Diagnosis of T-Cell Lymphoma	p. 197
Cloning of Immunoglobulin Chromosomal Translocations by Long-Distance Inverse Polymerase Chain Reaction	p. 217
Sequential Fluorescence In Situ Hybridization Analysis for Trisomy 12 in B-Cell Chronic Lymphocytic Leukemia	p. 231
Splenic Marginal Zone Lymphoma: 7q Abnormalities	p. 241
BCL-6: Rearrangement and Mutation in Lymphoma	p. 251
Antibody Techniques Used in the Study of Anaplastic Lymphoma Kinase-Positive ALCL	p. 271
Identification of Anaplastic Lymphoma Kinase Variant Translocations Using 5'RACE	p. 295
Follicular Lymphoma: Quantitation of Minimal Residual Disease by PCR of the t(14;18) Translocation	p. 315
Index	p. 333
Table of Contents provided by Publisher. All Rights Reserved.

Methods in Molecular Medicine

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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