Lectins

By: Nathan Sharon, H. Lis

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Paperback | 1 October 2007 | Edition Number 2

At a Glance

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476 Pages

Edition Type
Revised

Dimensions(cm)
23.5 x 15.88 x 2.54

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This is the second edition of our little red book Lectins published in 1989. In the intervening years well over 10,000 articles have appeared with lectins as the main subject, and more than twice as many in which they were touched upon, as well as around 20 books. In particular, great strides have been made in several areas of lectin research, about which little was known until the late 1980s. One prominent example is animal lectins, many of which have been discovered only during the last decade and the functions of several of which have been clarified, especially as to their key role in innate immunity. Another is the structure of lectins and of their combining sites. Thus, whereas at that time the three-dimensional structures of just three lectins and a few of their complexes with sugars had been elucidated, their numbers have increased to about 160 and over 200, respectively, and continue to grow unabated. Updating the information on these and other topics resulted in a marked expansion of the book, which is now nearly four times as long as the first edition, with 226 figures and 39 tables. Still, a few topics, such as carbohydrate-binding cytokines or bacterial toxins that are sometimes considered as lectins, have been dealt with only in passing. Similarly to the first edition, Lectins II starts with an overview of the history of lectin research.

Industry Reviews

"A must for everyone interested in Lectins."
(Robert A. Childs, MRC Glycosciences Laborartory, Imperial College, Harrow, UK in Microbiology Today, 31, November 2004)

"This excellent textbook, prepared by the authors, widely known as the top experts in the field, provides a comprehensive coverage of our present knowledge of structure, functions and applications in Lectins. The volume is very well illustrated by numerous excellent figures. The book is highly recommendable."
(Roald Nexlin, The Weizman Institute of Science, Israel in Immunological Investigations, 33:3, 2004)

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Non-Fiction Medicine Other Branches of Medicine Pathology Medical Microbiology & Virology Science Biology, Life Sciences Biochemistry Proteins

Preface	p. VII
Abbreviations	p. XV
Introduction	p. 1
History	p. 5
The Early Pioneers	p. 5
Blood Group Specificity	p. 12
Mitogenic Stimulation	p. 17
A Tool for Cancer Research	p. 20
Lectins Galore	p. 21
From Primary to Three-Dimensional Structures	p. 25
Tools for Biological and Medical Research	p. 26
Insight into Biological Functions	p. 29
Into Contemporary Lectin Research	p. 31
Detection, Occurence and Isolation	p. 33
Detection	p. 33
Occurrence	p. 36
Higher plants	p. 36
Lower plants	p. 43
Fungi (including mushrooms and yeasts)	p. 44
Animals	p. 45
Micrororganisms	p. 53
Isolation and Purification	p. 57
From natural sources	p. 57
By recombinant techniques	p. 60
Specificity and Affinity	p. 63
Methodology	p. 63
Carbohydrate Specificity	p. 66
Monosaccharides	p. 67
Sialic acids	p. 79
Oligosaccharides	p. 80
Promiscuous lectins	p. 87
Lectins with dual specificities	p. 88
Role of Oligosaccharide Conformation	p. 89
Effect of Multivalency	p. 90
Energetics of Protein-Carbohydrate Interactions	p. 97
Non-Carbohydrate Ligands	p. 101
Leczymes	p. 103
Molecular Structure	p. 105
Plant Lectins	p. 105
Legumes	p. 105
Cereals	p. 117
Amaryllidaceae and related monocots	p. 118
Moraceae and related plants	p. 122
Amaranthaceae	p. 125
Euphorbiaceae and Loranthaceae	p. 126
Solanaceae	p. 129
Labiatae	p. 130
Urticaceae	p. 132
Animal Lectins	p. 132
Galectins	p. 132
C-type lectins	p. 136
P-type lectins	p. 148
Pentraxins	p. 150
Siglecs	p. 151
Calnexin, calreticulin and calmegin	p. 153
ERGIC-53/MR60/p58	p. 156
Ficolins and intelectins	p. 156
Other animal lectins	p. 158
Protozoan Lectins	p. 161
Bacterial Lectins	p. 161
Soluble lectins	p. 162
Surface lectins	p. 164
Type 1 fimbriae	p. 164
P fimbriae	p. 168
Type IV pili (fimbriae)	p. 170
Other fimbriae	p. 170
Viral Hemagglutinins	p. 170
Influenza virus hemagglutinin	p. 170
Murine polyoma virus	p. 171
Foot-and-mouth disease virus	p. 172
Rhesus rotavirus	p. 172
Combining Sites	p. 175
Lectin-Carbohydrate Bonds	p. 175
Plant Lectins	p. 179
Legume lectins	p. 179
Binding sites for hydrophobic ligands	p. 197
Cereal lectins	p. 198
Amaryllidaceae and related monocots	p. 202
Moraceae and related plants	p. 206
Amaranthaceae	p. 209
Euphorbiaceae	p. 209
Urticaceae	p. 212
Animal Lectins	p. 213
Galectins	p. 213
C-type lectins	p. 216
P-type lectins	p. 224
Siglecs	p. 225
Calnexin	p. 226
ERGIC-53/MR60/p58	p. 227
Other animal lectins	p. 227
Bacterial Lectins	p. 230
Soluble lectins	p. 231
Surface lectins	p. 233
Other bacteria	p. 236
Viral Hemagglutinins	p. 236
Influenza virus	p. 236
Murine polyoma virus	p. 239
Foot-and-mouth disease virus	p. 239
Rhesus rotavirus	p. 240
Genetics, Molecular Biology and Evolution	p. 243
Genetics and Molecular Biology	p. 243
Plant lectins	p. 244
Animal lectins	p. 252
Bacterial lectins	p. 255
Viral lectins	p. 257
Evolution of Carbohydrate Binding Activity	p. 257
Applications	p. 261
Methodology	p. 262
Glycoconjugates in Solution	p. 263
Glycoproteins and polysaccharides	p. 263
Glycolipids	p. 273
Other carbohydrate derivatives	p. 276
Cell-Bound Carbohydrates	p. 279
Animal cells	p. 279
Microorganisms	p. 289
Mapping Neuronal Pathways	p. 293
Cell Separation	p. 294
Mitogenic Stimulation	p. 297
General features	p. 297
Mechanism of stimulation	p. 299
Antiadhesion Therapy	p. 302
Clinical Uses	p. 304
Blood typing	p. 304
Evaluation of immunocompetence	p. 305
Karyotyping	p. 307
Bone marrow transplantation	p. 307
Enzyme replacement therapy	p. 307
Diagnosis and Targeting	p. 308
Other Applications	p. 309
Lectin Cytotoxicity and Lectin-Resistant Cells	p. 313
Mechanism of Action	p. 314
Lectin-Resistant Mutants	p. 314
Loss-of-function mutants	p. 316
Gain-of-function mutants	p. 319
Functions of cell surface sugars	p. 322
Glycosylation engineering	p. 323
Nutritional Effects	p. 325
Lectins in Edible Plants	p. 325
Deleterious Effects in the Intestinal Tract	p. 327
Systemic Effects	p. 330
Functions	p. 333
Theoretical Considerations	p. 335
Plant Lectins	p. 336
Mediators of plant symbiosis with nitrogen-fixing bacteria	p. 336
Plant defense	p. 339
Animal Lectins	p. 342
Galectins	p. 342
C-Type lectins	p. 346
P-lectins	p. 354
Siglecs	p. 356
Calnexin, calreticulin and related lectins	p. 357
Sperm lectins	p. 359
CD44	p. 360
Microbial Lectins	p. 360
Fungi	p. 360
Protozoa	p. 361
Bacteria	p. 362
Viruses	p. 364
Monosaccharide Ligands of Lectins	p. 367
Oligosaccharide Ligands of Lectins	p. 371
References	p. 381
Index	p. 441
Table of Contents provided by Ingram. All Rights Reserved.

Lectins

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