Key Clinical Trials in Erectile Dysfunction

By: Culley C. Carson

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Paperback | 6 December 2006

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92 Pages

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20.32 x 13.34 x 1.27

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Contained within this short volume are some of the Key Clinical Trials relating to the medical treatment of erectile dysfunction (ED). In an attempt to understand the potential significance, a critique of the studies' strengths and weaknesses is included as well as a diagrammatic summary of the trial design and key results. Most of the studies have appeared in peer group reviewed journals and each trial included has been done so on the basis of the influence it will have on the treatment of ED. With the recent launch and continuing developments of new drugs in this field, the management of ED has become an increasingly important aspect of urological practice. It is estimated that over 20 million men in Europe alone suffer at some time in their life from ED. This is the first book to bring together in a single volume a critical review of all the major trials in ED.

It will be an essential reference for both clinicians and research workers in urology, sexual dysfunction and related disorders.

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Non-Fiction Medicine Clinical & Internal Medicine Urology & Urogenital Medicine Medicine in General Health Systems & Services General Practice

The Earliest Carefully Controlled Clinical Trial Evaluating Oral Pharmacotherapy (Yohimbine) in ED	p. 1
Key Trial References	p. 1
Importance of Study	p. 1
Study Design	p. 1
Key Results	p. 2
Conclusions from Original Reports	p. 3
Strengths	p. 3
Weaknesses	p. 3
Relevance	p. 3
A Description of the Pioneering Work That Led to the First Approved Agents for ED: Giles Brindley, the Needle, and the Penis (Phenoxybenzamine)	p. 4
Key Trial References	p. 4
Importance of Study	p. 4
Study Design	p. 4
Key Results	p. 5
Conclusions from Original Reports	p. 6
Strengths	p. 6
Weaknesses	p. 6
Relevance	p. 7
The Pivotal Study Showing That Intracorporal Injection of Vasoactive Agents (Papaverine or Phenoxybenzamine) Was Effective Pharmacotherapy	p. 8
Key Trial References	p. 8
Importance of Study	p. 8
Study Design	p. 8
Key Results	p. 9
Conclusions from Original Reports	p. 10
Strengths	p. 11
Weaknesses	p. 11
Relevance	p. 11
The First Placebo-Controlled Study on the Benefits of Intracorporal Administration of Vasorelaxant Agents to ED Patients (Papaverine/Phentolamine Combination)	p. 12
Key Trial References	p. 12
Importance of Study	p. 12
Study Design	p. 13
Key Results	p. 14
Conclusions from Original Reports	p. 15
Strengths	p. 15
Weaknesses	p. 15
Relevance	p. 15
Representative Study on the Use of Yohimbine in the Treatment of Organic ED	p. 16
Key Trial References	p. 16
Importance of Study	p. 16
Study Design	p. 16
Key Results	p. 18
Conclusions from Original Reports	p. 19
Strengths	p. 19
Weaknesses	p. 19
Relevance	p. 19
Defining the Therapeutic Ratio for Intracavernosal Administration of Prostaglandin E[subscript 1] (Alprostadil)	p. 20
Key Trial References	p. 20
Study Funding	p. 20
Importance of Study	p. 20
Study Design	p. 20
Key Results	p. 22
Conclusions from Original Reports	p. 23
Strengths	p. 23
Weaknesses	p. 23
Relevance	p. 23
An Elegant Long-Term Trial Assessing the Clinical Profile of Intracavernosal Prostaglandin E[subscript 1] (Alprostadil)	p. 24
Key Trial References	p. 24
Importance of Study	p. 24
Study Design	p. 24
Key Results	p. 25
Conclusions from Original Reports	p. 27
Strengths	p. 27
Weaknesses	p. 27
Relevance	p. 27
Evaluation of Novel Combination (Vasoactive Intestinal Polypeptide and Phentolamine) as Intracavernosal Therapy	p. 28
Key Trial References	p. 28
Study Funding	p. 28
Importance of Study	p. 28
Study Design	p. 29
Key Results	p. 30
Conclusions from Original Reports	p. 31
Strengths	p. 31
Weaknesses	p. 32
Relevance	p. 32
Now-Classic Study on the Use of Intraurethral Prostaglandin E[subscript 1] (Alprostadil)	p. 33
Key Trial References	p. 33
Study Funding	p. 33
Importance of Study	p. 33
Study Design	p. 33
Key Results	p. 35
Conclusions from Original Reports	p. 36
Strengths	p. 36
Weaknesses	p. 36
Relevance	p. 36
Route of Administration Has a Considerable Impact on Clinical Profile: A Comparison of Intraurethral and Intracavernosal Alprostadil	p. 37
Key Trial References	p. 37
Importance of Study	p. 37
Study Design	p. 37
Key Results	p. 38
Conclusions from Original Reports	p. 39
Strengths	p. 40
Weaknesses	p. 40
Relevance	p. 40
First Clinical Data on Sildenafil: The Arrival of Oral Pharmacotherapy	p. 41
Key Trial References	p. 41
Study Funding	p. 41
Importance of Study	p. 41
Study Design	p. 41
Key Results	p. 42
Conclusions from Original Reports	p. 43
Strengths	p. 43
Weaknesses	p. 44
Relevance	p. 44
Original "Gold Standard" Clinical Trial of Sildenafil in ED	p. 45
Key Trial References	p. 45
Study Funding	p. 45
Importance of Study	p. 45
Study Design	p. 45
Key Results	p. 47
Conclusions from Original Reports	p. 48
Strengths	p. 48
Weaknesses	p. 48
Relevance	p. 48
Pilot Study Showing Benefit of Clinical Response to Apomorphine Sublingual (SL)	p. 49
Key Trial References	p. 49
Study Funding	p. 49
Importance of Study	p. 49
Study Design	p. 50
Key Results	p. 51
Conclusions from Original Reports	p. 52
Strengths	p. 52
Weaknesses	p. 52
Relevance	p. 53
A Viable Alternative to PDE Inhibitors: Definition of Therapeutic Ratio of Apomorphine Sublingual (SL) in Patients with ED	p. 54
Key Trial References	p. 54
Study Funding	p. 54
Importance of Study	p. 54
Study Design	p. 54
Key Results	p. 56
Conclusions from Original Reports	p. 57
Strengths	p. 57
Weaknesses	p. 57
Relevance	p. 57
Summary of Clinical Trials of Phentolamine	p. 58
Key Trial References	p. 58
Importance of Study	p. 58
Study Design	p. 58
Key Results	p. 59
Conclusions from Original Reports	p. 60
Strengths	p. 60
Weaknesses	p. 61
Relevance	p. 61
Impact of Testosterone Replacement in Androgen- Deficient Males	p. 62
Key Trial References	p. 62
Study Funding	p. 62
Importance of Study	p. 62
Study Design	p. 62
Key Results	p. 63
Conclusions from Original Reports	p. 65
Strengths	p. 65
Weaknesses	p. 65
Relevance	p. 65
Evaluation of Psychotherapy for Patients and Partners	p. 66
Key Trial References	p. 66
Importance of Study	p. 66
Study Design	p. 66
Key Results	p. 67
Conclusions from Original Reports	p. 69
Strengths	p. 69
Weaknesses	p. 69
Relevance	p. 69
Quantification of Benefit of a Vacuum Device on Erectile Function	p. 70
Key Trial References	p. 70
Importance of Study	p. 70
Study Design	p. 70
Key Results	p. 71
Conclusions from Original Reports	p. 73
Strengths	p. 73
Weaknesses	p. 73
Relevance	p. 73
Pioneering Clinical Trial of Surgical Procedures	p. 74
Key Trial References	p. 74
Importance of Study	p. 74
Study Design	p. 74
Key Results	p. 75
Conclusions from Original Reports	p. 76
Strengths	p. 76
Weaknesses	p. 76
Relevance	p. 76
Index	p. 77
Table of Contents provided by Ingram. All Rights Reserved.

Key Clinical Trials in Erectile Dysfunction

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