
Interdisciplinary Applied Mathematics
Spatial Models and Biomedical Applications
By:Â James D. Murray
Hardcover | 27 January 2003 | Edition Number 3
At a Glance
844 Pages
Revised
23.39 x 15.6 x 4.45
Hardcover
$229.00
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Industry Reviews
From the reviews:
"The 2nd volume of the authors elucidating work highlights a surprisingly broad spectrum of applications in the field of mathematical biology. The sense given to the mathematical texture of thoughts broadens the reader's insight ... . The growing number of specialists in sub-disciplines of mathematical biology will be enjoying the truly concise approach ... . It can so be said that the foremost results ... might be essential for new interpretations of data ... . It is a recommended text for mathematicians ... ." (Daniel Gertsch, Bioworld, Issue 2, 2004)
From the reviews of the third edition:
"This is the second volume of the third edition of Murray's 'Mathematical Biology'. ... covers a wide variety of problems in pattern formation, each discussed in its biological context. ... This volume alone is a large book, with more than 800 pages and a similar number of references. ... it is a valuable collection of results from different areas of mathematical biology." (Carlo Laing, New Zealand Mathematical Society Newsletter, Issue 90, April, 2004)
"This book, a classical text in mathematical biology, cleverly combines mathematical tools with subject area sciences. The multi-layer way of material presentation makes the book useful for different types of reader including graduate-level students, bioscientists ... . it is an enjoyable reading and I recommend it to anyone with serious interest in mathematical modelling." (V.V. Fedorov, Short Book Reviews, Vol. 23 (3), 2003)
"This second volume of the third edition of Murray's Mathematical biology focuses on partial differential equations (spatial models) and their application to the biomedical sciences. ... Each chapter deals with its particular topic in great detail, usually focusing on one biological example and the associated mathematical model and results. This volume is not an introductory text ... making it extremely useful in graduate courses and for reference." (Trachette L. Jackson, Mathematical Reviews, 2004b)
"In this second volume ... the development towards specific biological configurations and towards a mechanism for understanding morphogenesis represents an important portion of the work. ... chapters deal with attractive topics ... . There is an extensive index at the end. ... very interesting and strongly recommended." (A. Akutowicz, Zentralblatt MATH, Vol. 1006, 2003)
"In this volume it becomes clear that compiling the third edition was a 'labor of love'. The book has a significantly different feel from the original first edition. ... my reaction to the third edition was positive. ... The historical and biological overviews have much interesting information. ... Certainly, the spicy writing will keep students alert ... . In summary, I recommend the new and expanded third edition to any serious young student interested in mathematical biology ... ." (Leah Edelstein-Keshet, SIAM Review, Vol. 46 (1), 2004)
"Mathematical Biology would be eminently suitable as a text for a final year undergraduate or postgraduate course in mathematical biology ... . It is also a good source of examples for courses in mathematical methods ... . Mathematical Biology provides a good way into the field and a useful reference for those of us already there. It may attract more mathematicians to work in biology by showing them that there is real work to be done." (Peter Saunders, The Mathematical Gazette, Vol. 90 (518), 2006)
| Preface to the Third Edition | p. vii |
| Preface to the First Edition | p. xi |
| Multi-Species Waves and Practical Applications | p. 1 |
| Intuitive Expectations | p. 1 |
| Waves of Pursuit and Evasion in Predator-Prey Systems | p. 5 |
| Competition Model for the Spatial Spread of the Grey Squirrel in Britain | p. 12 |
| Spread of Genetically Engineered Organisms | p. 18 |
| Travelling Fronts in the Belousov-Zhabotinskii Reaction | p. 35 |
| Waves in Excitable Media | p. 41 |
| Travelling Wave Trains in Reaction Diffusion Systems with Oscillatory Kinetics | p. 49 |
| Spiral Waves | p. 54 |
| Spiral Wave Solutions of [lambda]-[omega] Reaction Diffusion Systems | p. 61 |
| Exercises | p. 67 |
| Spatial Pattern Formation with Reaction Diffusion Systems | p. 71 |
| Role of Pattern in Biology | p. 71 |
| Reaction Diffusion (Turing) Mechanisms | p. 75 |
| General Conditions for Diffusion-Driven Instability: Linear Stability Analysis and Evolution of Spatial Pattern | p. 82 |
| Detailed Analysis of Pattern Initiation in a Reaction Diffusion Mechanism | p. 90 |
| Dispersion Relation, Turing Space, Scale and Geometry Effects in Pattern Formation Models | p. 103 |
| Mode Selection and the Dispersion Relation | p. 113 |
| Pattern Generation with Single-Species Models: Spatial Heterogeneity with the Spruce Budworm Model | p. 120 |
| Spatial Patterns in Scalar Population Interaction Diffusion Equations with Convection: Ecological Control Strategies | p. 125 |
| Nonexistence of Spatial Patterns in Reaction Diffusion Systems: General and Particular Results | p. 130 |
| Exercises | p. 135 |
| Animal Coat Patterns and Other Practical Applications of Reaction Diffusion Mechanisms | p. 141 |
| Mammalian Coat Patterns--'How the Leopard Got Its Spots' | p. 142 |
| Teratologies: Examples of Animal Coat Pattern Abnormalities | p. 156 |
| A Pattern Formation Mechanism for Butterfly Wing Patterns | p. 161 |
| Modelling Hair Patterns in a Whorl in Acetabularia | p. 180 |
| Pattern Formation on Growing Domains: Alligators and Snakes | p. 192 |
| Stripe Pattern Formation in the Alligator: Experiments | p. 193 |
| Modelling Concepts: Determining the Time of Stripe Formation | p. 196 |
| Stripes and Shadow Stripes on the Alligator | p. 200 |
| Spatial Patterning of Teeth Primordia in the Alligator: Background and Relevance | p. 205 |
| Biology of Tooth Initiation | p. 207 |
| Modelling Tooth Primordium Initiation: Background | p. 213 |
| Model Mechanism for Alligator Teeth Patterning | p. 215 |
| Results and Comparison with Experimental Data | p. 224 |
| Prediction Experiments | p. 228 |
| Concluding Remarks on Alligator Tooth Spatial Patterning | p. 232 |
| Pigmentation Pattern Formation on Snakes | p. 234 |
| Cell-Chemotaxis Model Mechanism | p. 238 |
| Simple and Complex Snake Pattern Elements | p. 241 |
| Propagating Pattern Generation with the Cell-Chemotaxis System | p. 248 |
| Bacterial Patterns and Chemotaxis | p. 253 |
| Background and Experimental Results | p. 253 |
| Model Mechanism for E. coli in the Semi-Solid Experiments | p. 260 |
| Liquid Phase Model: Intuitive Analysis of Pattern Formation | p. 267 |
| Interpretation of the Analytical Results and Numerical Solutions | p. 274 |
| Semi-Solid Phase Model Mechanism for S. typhimurium | p. 279 |
| Linear Analysis of the Basic Semi-Solid Model | p. 281 |
| Brief Outline and Results of the Nonlinear Analysis | p. 287 |
| Simulation Results, Parameter Spaces and Basic Patterns | p. 292 |
| Numerical Results with Initial Conditions from the Experiments | p. 297 |
| Swarm Ring Patterns with the Semi-Solid Phase Model Mechanism | p. 299 |
| Branching Patterns in Bacillus subtilis | p. 306 |
| Mechanical Theory for Generating Pattern and Form in Development | p. 311 |
| Introduction, Motivation and Background Biology | p. 311 |
| Mechanical Model for Mesenchymal Morphogenesis | p. 319 |
| Linear Analysis, Dispersion Relation and Pattern Formation Potential | p. 330 |
| Simple Mechanical Models Which Generate Spatial Patterns with Complex Dispersion Relations | p. 334 |
| Periodic Patterns of Feather Germs | p. 345 |
| Cartilage Condensations in Limb Morphogenesis and Morphogenetic Rules | p. 350 |
| Embryonic Fingerprint Formation | p. 358 |
| Mechanochemical Model for the Epidermis | p. 367 |
| Formation of Microvilli | p. 374 |
| Complex Pattern Formation and Tissue Interaction Models | p. 381 |
| Exercises | p. 394 |
| Evolution, Morphogenetic Laws, Developmental Constraints and Teratologies | p. 396 |
| Evolution and Morphogenesis | p. 396 |
| Evolution and Morphogenetic Rules in Cartilage Formation in the Vertebrate Limb | p. 402 |
| Teratologies (Monsters) | p. 407 |
| Developmental Constraints, Morphogenetic Rules and the Consequences for Evolution | p. 411 |
| A Mechanical Theory of Vascular Network Formation | p. 416 |
| Biological Background and Motivation | p. 416 |
| Cell-Extracellular Matrix Interactions for Vasculogenesis | p. 417 |
| Parameter Values | p. 425 |
| Analysis of the Model Equations | p. 427 |
| Network Patterns: Numerical Simulations and Conclusions | p. 433 |
| Epidermal Wound Healing | p. 441 |
| Brief History of Wound Healing | p. 441 |
| Biological Background: Epidermal Wounds | p. 444 |
| Model for Epidermal Wound Healing | p. 447 |
| Nondimensional Form, Linear Stability and Parameter Values | p. 450 |
| Numerical Solution for the Epidermal Wound Repair Model | p. 451 |
| Travelling Wave Solutions for the Epidermal Model | p. 454 |
| Clinical Implications of the Epidermal Wound Model | p. 461 |
| Mechanisms of Epidermal Repair in Embryos | p. 468 |
| Actin Alignment in Embryonic Wounds: A Mechanical Model | p. 471 |
| Mechanical Model with Stress Alignment of the Actin Filaments in Two Dimensions | p. 482 |
| Dermal Wound Healing | p. 491 |
| Background and Motivation--General and Biological | p. 491 |
| Logic of Wound Healing and Initial Models | p. 495 |
| Brief Review of Subsequent Developments | p. 500 |
| Model for Fibroblast-Driven Wound Healing: Residual Strain and Tissue Remodelling | p. 503 |
| Solutions of the Model Equations and Comparison with Experiment | p. 507 |
| Wound Healing Model of Cook (1995) | p. 511 |
| Matrix Secretion and Degradation | p. 515 |
| Cell Movement in an Oriented Environment | p. 518 |
| Model System for Dermal Wound Healing with Tissue Structure | p. 521 |
| One-Dimensional Model for the Structure of Pathological Scars | p. 526 |
| Open Problems in Wound Healing | p. 530 |
| Concluding Remarks on Wound Healing | p. 533 |
| Growth and Control of Brain Tumours | p. 536 |
| Medical Background | p. 538 |
| Basic Mathematical Model of Glioma Growth and Invasion | p. 542 |
| Tumour Spread In Vitro: Parameter Estimation | p. 550 |
| Tumour Invasion in the Rat Brain | p. 559 |
| Tumour Invasion in the Human Brain | p. 563 |
| Modelling Treatment Scenarios: General Comments | p. 579 |
| Modelling Tumour Resection in Homogeneous Tissue | p. 580 |
| Analytical Solution for Tumour Recurrence After Resection | p. 584 |
| Modelling Surgical Resection with Brain Tissue Heterogeneity | p. 588 |
| Modelling the Effect of Chemotherapy on Tumour Growth | p. 594 |
| Modelling Tumour Polyclonality and Cell Mutation | p. 605 |
| Neural Models of Pattern Formation | p. 614 |
| Spatial Patterning in Neural Firing with a Simple Activation-Inhibition Model | p. 614 |
| A Mechanism for Stripe Formation in the Visual Cortex | p. 622 |
| A Model for the Brain Mechanism Underlying Visual Hallucination Patterns | p. 627 |
| Neural Activity Model for Shell Patterns | p. 638 |
| Shamanism and Rock Art | p. 655 |
| Exercises | p. 659 |
| Geographic Spread and Control of Epidemics | p. 661 |
| Simple Model for the Spatial Spread of an Epidemic | p. 661 |
| Spread of the Black Death in Europe 1347-1350 | p. 664 |
| Brief History of Rabies: Facts and Myths | p. 669 |
| The Spatial Spread of Rabies Among Foxes I: Background and Simple Model | p. 673 |
| The Spatial Spread of Rabies Among Foxes II: Three-Species (SIR) Model | p. 681 |
| Control Strategy Based on Wave Propagation into a Nonepidemic Region: Estimate of Width of a Rabies Barrier | p. 696 |
| Analytic Approximation for the Width of the Rabies Control Break | p. 700 |
| Two-Dimensional Epizootic Fronts and Effects of Variable Fox Densities: Quantitative Predictions for a Rabies Outbreak in England | p. 704 |
| Effect of Fox Immunity on the Spatial Spread of Rabies | p. 710 |
| Exercises | p. 720 |
| Wolf Territoriality, Wolf-Deer Interaction and Survival | p. 722 |
| Introduction and Wolf Ecology | p. 722 |
| Models for Wolf Pack Territory Formation: Single Pack--Home Range Model | p. 729 |
| Multi-Wolf Pack Territorial Model | p. 734 |
| Wolf-Deer Predator-Prey Model | p. 745 |
| Concluding Remarks on Wolf Territoriality and Deer Survival | p. 751 |
| Coyote Home Range Patterns | p. 753 |
| Chippewa and Sioux Intertribal Conflict c1750-1850 | p. 754 |
| Appendix | |
| General Results for the Laplacian Operator in Bounded Domains | p. 757 |
| Bibliography | p. 761 |
| Index | p. 791 |
| Table of Contents provided by Syndetics. All Rights Reserved. |
ISBN: 9780387952284
ISBN-10: 0387952284
Series: Interdisciplinary Applied Mathematics
Published: 27th January 2003
Format: Hardcover
Language: English
Number of Pages: 844
Audience: General Adult
Publisher: Springer Nature B.V.
Country of Publication: GB
Edition Number: 3
Edition Type: Revised
Dimensions (cm): 23.39 x 15.6 x 4.45
Weight (kg): 1.32
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