Advances in Experimental Medicine and Biology

Epigenetic Mechanisms as an Interface Between the Environment and Genome.- Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans.- Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.- Epigenetics in Cardiovascular Regulation.- Why Are High Altitude Native So Strong at Altitude?: Maximal Oxygen Transport to the Muscle Cell in Altitude Natives.- Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness.- Why Are High Altitude Natives So Strong at High Altitude?: Nature vs. Nurture.- Functional Genomic Insights into Regulatory Mechanisms of High Altitude Adaptation.- Influence of Hypoxia on Cerebral Blood Flow Regulation.- Imaging the Respiratory Effects of Opioids in the Human Brain.- Regional Cerebrovascular Responses to Hypercapnia and Hypoxia.- Implications of Oxygen Homeostasis for Brain Tumors: Biology and Treatment.- Hyperoxia and Functional MRI.- Astrocytes and Brain Hypoxia.- Bidirectional Control of Blood Flow by Astrocytes: A Role for Tissue Oxygen and Other Metabolic Factors.- Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration.- Optical Analysis of Hypoxia Inducible Factor (HIF)-1 Complex Assembly: Imaging of Cellular Oxygen Sensing.- Modulation of the Hypoxic Response.- Central Sleep Apnea at High Altitude.- Multigenerational Effects of Reading Atmospheric Oxygen Level on the Tracheal Dimensions and Diffusing Capacities of Pupal and Adult Drosophila Melanogaster.- Hypoxia and Its Acid-base Consequences: From Mountains to Malignancy.- Physiological and Clinical Implications of Adrenergic Pathways at High Altitude.- Hemoglobin Mass and Aerobic Performance at Moderate Altitude in Elite Athletes.- Does the Sympathetic Nervous System Adapt to Chronic Altitude Exposure?.- Integrative Conductance of Oxygen During Exercise at Altitude.- Modeling Variable Phanerozoic Oxygen Effects on Physiology and Evolution.- Caudwell Xtreme Everest: An Overview.- Energy Flux, Lactate Shuttling, Mitochondrial Dynamics, and Hypoxia.- Everest Physiology Pre-2008.