Hormesis

A Revolution in Biology, Toxicology and Medicine

By: Mark P. Mattson (Editor), Edward J. Calabrese (Editor)

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Paperback | 26 November 2014

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Paperback
228 Pages

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23.5 x 15.49 x 1.22

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The term hormesis is de?ned as "a process in which exposure to a low dose of a chemical agent or environmental factor that is damaging at higher doses induces an adaptive bene?cial effect on the cell or organism" (Calabrese et al., 2007; Mattson, 2008). To survive and reproduce in harsh competitive environments, organisms and their cellular components have, through evolution, developed molecular mec- nisms to respond adaptively to various hazards or "stressors" that they encounter. Examples of such stressors include chemicals ingested in food and water (metals, phytochemicals, etc.), increased energy expenditure (running, ?ghting, cognitive challenges, etc.), and reduced energy availability (food scarcity), among others. In most cases, the response of the cell or organism to the stressor exhibits a biphasic dose response, with bene?cial/adaptive responses at low doses (improved fu- tion, increased resistance to damage and disease) and adverse/destructive effects (dysfunction, molecular damage, or even death) at high doses. The prevalence of the biphasic (hormetic) dose response characteristic of biological systems merits consideration of hormesis as a fundamental principle of biology.

Industry Reviews

From the reviews:

"'Hormesis: a revolution in biology, toxicology and medicine' is a very interesting and well- written book organized by two expressive authors in neuroscience and the health environment. ... The book is divided into 10 chapters, each written by a group of authors, describing the concept of hormesis ... . book concludes by proposing a fresh look at the modern pharmacy of natural products and man-made drugs. It is a pleasant read for anyone interested in toxicology, environmental health and pharmacology." (Tania Marcourakis, Brazilian Journal of Pharmaceutical Sciences, May, 2010)

"This book argues that hormesis (biphasic dose-response patterns) is an underlying process at all levels of biological organization. ... The book appears to be written for risk assessors and researchers interested in dose-response relationships and cellular signaling pathways. ... Physically, the book is nicely laid out with high-quality illustrations that enhance the text. The concept of the hormetic dose-response curve is worth further study, and may well lead to advances in pharmacology and other biomedical applications." (Jennifer Gervais, Doody's Review Service, February, 2011)

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