Essentials in Ophthalmology

By: Franz Grehn (Editor), Robert Stamper (Editor)

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Hardcover | 25 May 2004

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248 Pages

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24.77 x 17.78 x 1.91

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This first volume of the series Essentials in Ophthalmology aims to give a picture of recent progress in the field of glaucoma, in both basic clinical research and applied clinical science. Its intention is not to replace textbooks on glaucoma, but to serve as a conceptual bridge between original research and textbook presentation. The volume encompasses (a) genetic aspects of different forms of glaucoma, such as normal tension glaucoma, pseudoexfoliative glaucoma, childhood glaucoma, and angle closure glaucoma, (b) methods of diagnosis, such as imaging techniques, visual fields, electrophysiology, and ultrasound biomicroscopy, and (c) aspects of therapy, such as the target pressure concept, wound modulation in glaucoma surgery, neuroprotection, treatment of normal tension glaucoma, and the evaluation of nonpenetrating surgery. The editors have set out to provide the reader with a diversity of interesting topics reflective of the evidence-based, modern approach to the field of glaucoma.

Industry Reviews

From the reviews: "The Essentials in Ophthalmology series attempts to bridge the time gap between journal publications and up-to-date textbook distillation of medical knowledge. ! The editors of this series have cleverly packaged information in a format that will keep clinicians on the forefront of thoughts in the different disciplines of ophthalmology. ! Readers will be relieved and undoubtedly satisfied with this concise text that provides clinically useful updates in important areas of glaucoma diagnosis and management." (L. J. Katz, Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 244, 2006)

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Non-Fiction Medicine Clinical & Internal Medicine Ophthalmology Science Science in General Nursing & Ancillary Services Nursing Nursing Research & Theory

Genetic Changes and Their Influence on Structure and Function of the Eye in Glaucoma
Introduction	p. 1
Glaucoma in Developmental Disorders	p. 2
Development of the Ocular Mesenchyme in the Anterior Eye	p. 2
Axenfeld-Rieger's Syndrome, Peters' Anomaly and Anterior Segment Dysgenesis	p. 4
Aniridia	p. 9
Primary Congenital Glaucoma	p. 11
Nail-Patella Syndrome	p. 13
Genes and Primary Open-Angle Glaucoma (POAG)	p. 13
Loci for POAG	p. 14
Myocilin	p. 15
Optineurin	p. 19
Genes and Pigmentary Glaucoma	p. 21
References	p. 21
Neuroprotection in Glaucoma
Introduction	p. 29
Basics	p. 29
Rationale for Neuroprotection in Glaucoma	p. 30
Necessary Steps for Neuroprotection	p. 31
Preclinical Evidence for Neuroprotection in Glaucoma	p. 31
NMDA Receptor Antagonists	p. 31
2-Adrenergic Receptor Agonists	p. 32
ß1-Adrenergic Receptor Antagonists	p. 32
Nitric Oxide Synthase Antagonists	p. 33
Reactive Oxygen Species Scavengers and Lipid Peroxidation Inhibitors	p. 33
Neurotrophic Factors	p. 33
Vaccination	p. 34
Clinical Experience with the Described Substances	p. 34
Current Clinical Practice/Recommendations	p. 36
References	p. 36
Screening for Glaucoma
Introduction	p. 39
Why Screen for Glaucoma?	p. 40
The Burden of Untreated Disease	p. 40
The Importance of Early Detection	p. 41
The Lack of Knowledge Regarding Glaucoma in the Lay Community	p. 41
Current Screening Practices and Experience	p. 42
Specific Screening Tests	p. 43
Rationale for a Risk Factor Questionnaire	p. 43
Frequency-Doubling Technology	p. 43
Scanning Laser Polarimetry	p. 44
The Promise of Teleophthalmology	p. 46
The Cost-Effectiveness of Screening for Glaucoma	p. 46
References	p. 49
Semi-automated Kinetic Perimetry for Assessment of Advanced Glaucomatous Visual Field Loss
Introduction	p. 51
Methods/Methodological Aspects	p. 52
Assessment and Definition of "Local Kinetic Threshold" and Local Scatter	p. 57
Assessment and Importance of Individual Reaction Time	p. 57
Selection of Optimum Target Angular Velocity	p. 58
Age-Related Normative Values	p. 58
Comparability of SKP Results with Those of Conventional Manual Kinetic Perimetry Using the GOLDMANN Instrument	p. 58
Evaluation of Individual Functional Impairment/Expert Opinion	p. 59
Training, Education and Learning	p. 59
Outlook	p. 59
References	p. 60
Optic Nerve Imaging: Recent Advances
Introduction	p. 63
Background	p. 63
Image Quality	p. 65
Reproducibility	p. 66
Detecting Glaucoma	p. 66
Association Between Structure and Function	p. 66
Detecting Change Over Time	p. 66
Confocal Scanning Laser Ophthalmoscopy	p. 67
Background	p. 67
Image Quality	p. 71
Reproducibility	p. 71
Detecting Early to Moderate Glaucoma	p. 72
Relationship Between Structure and Function	p. 72
Detecting Change Over Time	p. 72
Strengths and Limitations	p. 74
Scanning Laser Polarimetry	p. 74
Background	p. 74
Image Quality	p. 76
Reproducibility	p. 76
Detecting Early to Moderate Glaucoma	p. 76
Relationship Between Structure and Function	p. 78
Detecting Change Over Time	p. 78
Strngths and Limitations	p. 78
Optical Coherence Tomography	p. 79
Background	p. 79
Image Quality	p. 81
Reproducibility	p. 82
Detecting Early to Moderate Glaucoma	p. 82
Relationship Between Structure and Function	p. 83
Detection of Longitudinal Change over Time	p. 84
Strengths and Limitations	p. 85
Scanning Retinal Thickness Analyzer	p. 85
Background	p. 85
Image Quality	p. 86
Reproducibility	p. 86
Discriminating Between Healthy Eyes and Eyes with Early to Moderate Glaucoma	p. 86
Relationship Between Structure and Function	p. 86
Detecting Change Over Time	p. 87
Strengths and Limitations	p. 87
Conclusions	p. 87
References	p. 88
New Concepts in the Diagnosis of Angle-Closure Glaucoma: The Role of Ultrasound Biomicroscopy
Introduction	p. 93
Ultrasound Biomicroscopy	p. 94
The Normal Eye	p. 96
Anatomical Classification of the Angle-Closure Glaucomas	p. 96
Pupillary Block	p. 96
Plateau Iris	p. 99
Pseudoplateau Iris	p. 100
Lens-Related Angle-Closure	p. 100
Malignant Glaucoma	p. 102
Conclusion	p. 103
References	p. 103
Childhood Glaucoma and Amblyopia
Introduction	p. 105
Patient Evaluation	p. 106
Clinical Features	p. 106
Examination Under Sedation	p. 106
Examination Under Anesthesia (EUA)	p. 107
Special Diagnostic Tests	p. 109
Medical Management	p. 109
Indications	p. 109
Efficacy and Safety	p. 109
Surgical Management	p. 110
Goniotomy	p. 110
Trabeculotomy	p. 111
Trabeculectomy	p. 113
Goniotomy versus Trabeculotomy versus Trabeculectomy versus Other Procedures	p. 115
Glaucoma Drainage Implants	p. 117
Cyclodestructive Procedures	p. 118
Postoperative Management	p. 119
Periodic Clinical Examination	p. 119
Management of Amblyopia	p. 119
Genetic Counseling	p. 121
Conclusions	p. 121
References	p. 122
What Have We Learned from the Major Glaucoma Clinical Trials?
Introduction	p. 125
Advanced Glaucoma Intervention Study (AGIS)	p. 127
Collaborative Normal Tension Glaucoma Study (CNTGS)	p. 129
Collaborative Initial Glaucoma Treatment Study (CIGTS)	p. 130
Ocular Hypertension Treatment Study (OHTS)	p. 131
Early Manifest Glaucoma Trial (EMGT)	p. 135
Conclusions	p. 136
References	p. 136
The Concept of Target IOP at Various Stages of Glaucoma
Introduction	p. 139
The Relationship Between IOP and the Risk of Visual Field Progression	p. 140
Target Pressures in Glaucoma Management	p. 140
Target Pressure	p. 140
Randomized Controlled Trials and Target IOPs	p. 143
References	p. 145
A Practical Approach to the Management of Normal Tension Glaucoma
Introduction	p. 147
Background	p. 147
Differential Diagnosis	p. 148
Investigation	p. 151
Investigation for the Purpose of Management	p. 152
Management	p. 153
References	p. 155
Pseudoexfoliation Glaucoma
Background	p. 157
Pathobiology of PEX Syndrome	p. 158
Pathogenesis	p. 158
Pathogenetic Factors	p. 160
Pathogenetic Concept	p. 160
Etiology	p. 160
Clinical Diagnosis	p. 161
Manifest PEX Syndrome	p. 161
Masked PEX Syndrome	p. 163
Early Stages of PEX Syndrome	p. 164
Asymmetry of Involvement	p. 164
Differential Diagnosis	p. 164
Open-Angle Glaucoma in PEX Syndrome	p. 165
Epidemiology	p. 165
Clinical Features	p. 165
Pathomechanisms of Glaucoma Development	p. 166
Acute Open-Angle Glaucoma	p. 170
Angle-Closure Glaucoma in PEX Syndrome	p. 170
Management	p. 171
Medical Therapy	p. 172
Laser Trabeculoplasty	p. 172
Filtration Surgery	p. 172
Summary and Perspectives	p. 173
References	p. 174
Pigment Dispersion Syndrome-Update 2003
Introduction	p. 177
Clinical Findings	p. 177
Anterior Segment	p. 177
Posterior Segment	p. 179
Pathophysiology	p. 179
Developmental Abnormalities Underlying PDS	p. 181
Blinking	p. 182
Accommodation	p. 183
Exercise	p. 183
Clinical Correlations	p. 183
Heredity	p. 183
Gender	p. 183
Race	p. 184
Refractive Error	p. 184
Asymmetric Involvement	p. 184
Natural History	p. 184
Active Phase	p. 184
Regression Phase	p. 185
Conversion to Glaucoma	p. 185
Differential Diagnosis	p. 185
Treatment	p. 186
References	p. 188
Wound Modulation in Glaucoma Surgery
Introduction	p. 193
Basics	p. 193
Wound Healing Following Trabeculectomy	p. 193
Therapeutic Options	p. 194
Clinical Experience with the Described Substances	p. 196
Corticosteroids	p. 196
5-Fluorouracil	p. 197
Mitomycin	p. 199
Transforming Growth Factor-ß	p. 205
Suramin	p. 206
Additional Substances	p. 206
Current Clinical Practice/Recommendations	p. 206
Post-operative Intensified Care	p. 207
References	p. 207
Non-penetrating vs Penetrating Surgery of Primary Open-Angle Glaucoma
Introduction	p. 209
Basics	p. 209
Non-penetrating vs Penetrating Procedures: Clinical Evaluation	p. 211
Efficacy	p. 211
Safety	p. 212
Affordability	p. 213
Conclusions	p. 214
References	p. 214
Subject Index	p. 217
Table of Contents provided by Publisher. All Rights Reserved.

Essentials in Ophthalmology

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

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