The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine. The first section lays foundation to the practice of genomic medicine. New chapters in this section include bioinformatics, proteomics, microbial genomics and genomic education. Detailed discussions of genetic/genomic testing and screening and the ethical, legal, and social issues (ELSI) crucially address genethics and genomethics in the practice of Genomic Medicine.
The second section includes clinical practice oriented chapters highlighting genomic applications (array comparative genomic hybridization, exome genome sequencing and new generation generation sequencing) in clinical diagnosis of congenital developmental malformations, Mendelian genetic disorders, and complex cardiovascular, neuro-psychiatric, ophthalmic, dermatologic, inflammatory and pediatric disorders. Separate chapters discuss microbial genomics with emphasis on the role of genomics in targeted antimicrobial therapy and development of genomic class of new vaccines. New developments in gene/ cell-based somatic therapy, regenerative medicine and targeted molecular therapy are discussed in respective chapters. All chapters are thoroughly indexed and supported by a carefully compiled glossary relevant to genetic and genomic medicine.
Industry Reviews
"Genomics and Clinical Medicine is the first textbook to comprehensively examine Medicine, especially pathophysiology and pathogenesis, through the lens of genomics." --JAMA
"...written by an equally outstanding roaster of authors, deal with all aspects of Genomic Medicine. The book combines general principles, and specific aspects of clinical practice, all in the light of genome analysis and the current laboratory methodologies." --Stylianos E. Antonarakis, Professor and Chairman of Genetic Medicine, University of Geneva, President of Human Genome Organization, Geneva, Switzerland
"...most physicians have had little or no training in genetics or genomics, and will be hard pressed to quickly acquire the scientific principles, the medical knowledge, and the psychosocial skills that will be necessary for the successful introduction of genomic medicine. Busy practitioners will desperately need an authoritative source of information that includes both principles and specific applications. The introduction of this textbook, with its
distinguished and authoritative list of contributors, thus arrives in the nick of time. Welcome to the genome era." --Francis S. Collins, National Human Genome Research Institute, National Institutes of Health,
Bethesda, MD, USA
"...the book is a nice overview of developments in different fields of genomic medicine, written by a number of experts who give a thorough description of their argument." --European Journal of Human Genetics
"Genomics and Clinical Medicine could be used during the first or second year of medical school to provide an underpinning of genomics as a unifying theme to the diverse array of topics that are typically taught at this time." --New England Journal of Medicine
"This is a pioneering work of two doctors who as editors, have undertaken a monumental project, compiling a lot of relatively new knowledge put on paper by a total 50 pioneers in genomic medicine. All the authors and Drs. Kumar and Eng are to be congratulated for this unique, massive contribution to better understanding of disease so that eventually, millions of people can benefit from their work, to lead healthier lives." -- Biz India Book Review
"This innovative and unique book is difficult to compare to others as the editors have done an extremely good job. Congratulations to the editors and the wonderful group of contributors for a provocative and inviting book. Weighted Numerical Score: 100 - 5 Stars!" -- Doody's Health Sciences Review
