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Genome-Scale Algorithm Design : Bioinformatics in the Era of High-Throughput Sequencing - Veli Mäkinen

Genome-Scale Algorithm Design

Bioinformatics in the Era of High-Throughput Sequencing

By: Veli Mäkinen, Djamal Belazzougui, Fabio Cunial, Alexandru I. Tomescu

eText | 12 October 2023 | Edition Number 2

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Presenting the fundamental algorithms and data structures that power bioinformatics workflows, this book covers a range of topics from the foundations of sequence analysis (alignments and hidden Markov models) to classical index structures (k-mer indexes, suffix arrays, and suffix trees), Burrows-Wheeler indexes, graph algorithms, network flows, and a number of advanced omics applications. The chapters feature numerous examples, algorithm visualizations, and exercises, providing graduate students, researchers, and practitioners with a powerful algorithmic toolkit for the applications of high-throughput sequencing. An accompanying website (www.genome-scale.info) offers supporting teaching material. The second edition strengthens the toolkit by covering minimizers and other advanced data structures and their use in emerging pangenomics approaches.
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