Genome Dynamics and Stability

Facets and Perspectives

By: Dirk Lankenau (Editor)

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Hardcover | 7 November 2006

At a Glance

Hardcover
512 Pages

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23.5 x 15.88 x 3.18

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Cells and viruses maintain a genome capable of multiplication, variation and heredity. A genome consists of chromosomes, each being built up of two complementary strands of nucleic acid known as DNA. Its chemical integrity, however, is under constant assault from metabolic mutagens, such as hydroxy-radicals, endonucleases, radiation, replication errors, and environmental mutagens. From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.

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Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Biochemistry Cellular Biology Medicine Pre-Clinical Medicine & Basic Sciences Medical Genetics Molecular Biology

Chromosomal DNA replication : on replicases, replisomes, and bidirectional replication factories	p. 3
Progress towards the anatomy of the eukaryotic DNA replication fork	p. 27
DNA polymerases and diseases	p. 69
Facing stalled replication forks : the intricacies of doing the right thing	p. 105
Germline double-strand break repair and gene targeting in Drosophila : a trajectory system throughout evolution	p. 153
Structure and function of Rad50/SMC protein complexes in chromosome biology	p. 201
Mechanisms of non-homologous DNA end joining : aspects of in vitro assays	p. 219
Role of p53 in double-strand break repair	p. 243
The role of chromatin structure and nuclear architecture in the cellular response to DNA double-strand breaks	p. 267
DNA base damage recognition and processing	p. 287
Inter- and supramolecular interactions of protein kinase CK2 and their relevance for genome integrity	p. 315
Role of human topoisomerase I in DNA repair and apoptosis	p. 343
Genomic instability in Fanconi anaemia and Nijmegen breakage syndrome	p. 363
Induction of DNA repair genes in mammalian cells in response to genotoxic stress	p. 383
Pathways of DNA double-strand break repair in mammalian cells after ionizing radiation	p. 399
Genomic instability : signaling pathways orchestrating the responses to ionizing radiation and cisplatin	p. 423
Ion irradiation as a tool to reveal the spatiotemporal dynamics of DNA damage response processes	p. 453
Table of Contents provided by Blackwell. All Rights Reserved.

Genome Dynamics and Stability

Facets and Perspectives

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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