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440 Pages
23.5 x 16.51 x 3.18
Hardcover
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This study covers key aspects in the field of biotechnology, with topics ranging from genome projects, through animal and human cloning, to biowarfare. The author presents firsthand accounts from both the scientific and the business perspective. The work is addressed primarily to experts and professionals who are very busy but who wish to gain insights through a different and comprehensive perspective of this important field. It is also aimed at laypeople who are interested in learning more about bioinformatics, and the biotechnology, pharmaceutical, and healthcare industries. Each chapter is self-contained and footnotes provide further references for interested readers.
Industry Reviews
| Preface | p. ix |
| The Genome Project: Its Impacts and Implications | p. 1 |
| Looking Back In The Future | p. 1 |
| Lewis-Clark De Javu | p. 2 |
| The Human Genome Tour | p. 3 |
| Historical Perspective--The Timeline Of The Human Genome Project | p. 5 |
| Pre-genomic Sequencing Cottage Industry | p. 5 |
| Scaling up a la Big Science--A Biological Moonshot, A Biological Particle Smasher | p. 6 |
| Enters the Black Knight | p. 7 |
| Divide-and-Conquer Strategy | p. 8 |
| Shotgun Strategy | p. 9 |
| The Traveling Salesman Is a Chinese Postman | p. 10 |
| The Race to the Finishing Line--Bigger is Better | p. 11 |
| Complementary Strategies--Ally or Foe | p. 12 |
| From Genome Marathon to Sprint to the Finishing Line | p. 13 |
| The Gutenberg Press of the Human Genome Project | p. 13 |
| A Small Step For Genome, A Giant Step For Humankind | p. 17 |
| Impacts and Implications--Deciphering the Rosetta Tablet | p. 19 |
| What Is In Store? | p. 23 |
| Gaps Filling | p. 23 |
| Gene Finding | p. 24 |
| Other Genomes | p. 24 |
| Gene Function | p. 26 |
| Single Nucleotide Polymorphisms | p. 26 |
| The Eclectic Bioinformatics | p. 26 |
| An Array of Possibilities--New Genomic Technologies | p. 27 |
| The Next Fifty Years | p. 27 |
| The Test Of Time | p. 29 |
| Post-Genomics Matters: Send out A Thousand Ships, Not Catalogue a Thousand Genes | p. 33 |
| Genome Armada | p. 33 |
| Perplexity And Enlightenment | p. 33 |
| The New Genetic Math--1.5 x Caenorhabditis elegans = Homo sapiens | p. 34 |
| Human Genome Archaeology | p. 37 |
| The Genome Topography | p. 38 |
| How The Statistics Stack Up? | p. 41 |
| On the Pessimistic Side | p. 41 |
| On the Mixed Side | p. 42 |
| On the Positive and Opportunistic Side | p. 42 |
| Comparatively Speaking | p. 43 |
| Genestimate Discrepancies | p. 44 |
| Humbled by Our Own Ego Genes | p. 45 |
| Genome--A Map To Profitability? | p. 47 |
| Biotech Bay, Biotech Beach, Biotech Beltway, Biotech Corridor | p. 49 |
| Biotechnology Tools: Friends or Foes? | p. 50 |
| The Other Sequencing Centers | p. 51 |
| From The Book Of Life To Inventory Of Life | p. 53 |
| AgBiotechnology: Genetically Modified | p. 55 |
| The Biotech Revolution | p. 55 |
| Mother Nature, Father Time and Author Children | p. 56 |
| From Green Revolution To AgBiotech Revolution | p. 57 |
| Genetically Modified Crops | p. 58 |
| Genetically Modified Trees | p. 61 |
| Genetically Engineered Animals | p. 63 |
| Genetically Modified Microbes | p. 64 |
| Germ Warfare Agents | p. 65 |
| Biotech Backlash | p. 66 |
| StarLink For Hogs, Not Humans | p. 67 |
| FDA Snafu | p. 70 |
| Bt Not for Butterflies | p. 71 |
| Corn Dogs | p. 74 |
| The Extent of Commingling | p. 74 |
| Organic Food | p. 75 |
| Long Term Ramifications | p. 76 |
| From Taco to Genes | p. 77 |
| Warranty of Edibility | p. 77 |
| Aqua Biotechnology | p. 79 |
| The Fish Tale | p. 79 |
| Need For Aquaculture | p. 80 |
| Gene Transfer Protocol in Fish | p. 80 |
| Fish As Medical Tools | p. 81 |
| The Rule of the Game--Growth Enhancement | p. 87 |
| Antifreeze | p. 88 |
| Disease Resistance | p. 89 |
| Gene Transfer In Fish | p. 89 |
| Transgenic Fish | p. 91 |
| Carp--Food and See Food | p. 91 |
| The Tale of Catfish--Transgenic Creole | p. 94 |
| Salmon for Sushi | p. 96 |
| Shrimps | p. 98 |
| The Prospect Of Transgenic Fish | p. 99 |
| Other Fish To Fry | p. 100 |
| Clonology and Clonetechnology | p. 103 |
| The Genetic Age | p. 103 |
| Clonolgy | p. 104 |
| Parthenogenesis--Virgin Birth | p. 104 |
| Photocopying Life Forms | p. 104 |
| Win a Clone at the Diary Expo | p. 107 |
| Clonetechnology | p. 109 |
| The Celebrated Dolly | p. 109 |
| Monkeying with Nature | p. 112 |
| Sheep Factory | p. 113 |
| Dolly, Polly and "Holly" Calf | p. 115 |
| Got Milk? Goat Milk | p. 115 |
| Second Chance--Clone of the Oldest Bull | p. 116 |
| Artificial Monkey Twins | p. 118 |
| Inserted DNA and ANDi | p. 119 |
| Clone of a Clone--More Bulls | p. 120 |
| Five Piglets: Oink! Oink! Oink! Oink! Oink!--Organs for Sale | p. 121 |
| Spring Holy Cows | p. 123 |
| Xena--No Warrior Princess but a Piglet | p. 126 |
| Cow Pregnant with Clone--Jurassic Amusement Park | p. 129 |
| No Jurassic Amusement Yet | p. 130 |
| Pet Cloning And BioFactory | p. 133 |
| Attempts At Cloning | p. 133 |
| Cell Specialization | p. 133 |
| Embryo Splitting | p. 135 |
| Gaps in Cell Cycle | p. 136 |
| Cloning Techniques | p. 136 |
| Embryo Splitting Technique | p. 136 |
| The Nuclear Transfer Technique | p. 137 |
| From Barnyard To PerPETually Yours | p. 143 |
| K-9 Cloning | p. 145 |
| Feline the Copy Cat | p. 145 |
| Which Comes First? The Chicken Or The Egg? | p. 146 |
| White Elephant | p. 147 |
| A Mammoth Undertaking | p. 148 |
| Animal Factory--From Farming To Pharming | p. 150 |
| Animal Bioreactors | p. 151 |
| Key Transgenic Players and Future Trends | p. 156 |
| Barnyard Organ and Tissue Shops | p. 158 |
| Barnyard Teats as Spinnerets--Silk in Milk | p. 163 |
| Ethical Issues And Regulatory Compliance | p. 164 |
| Human Cloning And Stem Cell Research | p. 167 |
| Human Cloning, To Be Or Not To Be? | p. 167 |
| Politics Of Cloning | p. 168 |
| To Be Or Not To Be, That Is The Question | p. 169 |
| The Good--Medical Applications | p. 170 |
| The Bad--Clandestine Efforts | p. 171 |
| The Ugly--Cloning Misconceptions | p. 172 |
| Louis Brown Of Cloning | p. 173 |
| Infertile Parents | p. 173 |
| Carriers of Defective Genes | p. 174 |
| Issues | p. 175 |
| The Question of Identity--Like Father Like Son | p. 176 |
| Silver Linings | p. 176 |
| The Dark Cloud--All Is Fine Unless You Are The Clone | p. 177 |
| Dream Things That Never Were | p. 181 |
| The Law | p. 182 |
| The Genie Is Out of the Bottle into The Brave New World | p. 183 |
| Message In A Bottle From The Future | p. 184 |
| Sherlock Holmes--The Clone Murder Detective | p. 185 |
| Stem Cell Research | p. 186 |
| Stem Cell 101 | p. 186 |
| Derivation of Stem Cells | p. 187 |
| Sources of Embryos | p. 188 |
| Applications of Stem Cell Research | p. 189 |
| From Degenerative Disorders to Regenerative Medicines | p. 190 |
| Embryonic Stem Cells versus Adult Stem Cells | p. 190 |
| Federal Support | p. 191 |
| Private Companies In Stem Cell Business | p. 191 |
| Reactions To Bush's Decision | p. 192 |
| What Next? | p. 193 |
| Hotbed For Stem Cell Research--University Of Wisconsin | p. 195 |
| 6,200,806 | p. 195 |
| 6,200,806 Reasons to Worry About | p. 195 |
| Hot Off The Press | p. 197 |
| Genomic And Proteomic Technologies And Beyond | p. 199 |
| Biochip | p. 199 |
| The DNA Chip Technology | p. 200 |
| The DNA Chip Array | p. 201 |
| Formats | p. 202 |
| Applications of DNA Microarray Technology | p. 204 |
| Biochip Market | p. 207 |
| Market Segments | p. 208 |
| Microchip But Macro Impacts | p. 210 |
| A Chip off the Old Block | p. 210 |
| Future Outlook | p. 212 |
| Challenges | p. 212 |
| Future Development | p. 212 |
| Crossing The Chasm From Genomics To Proteomics | p. 214 |
| The Cell, DNA and Protein Synthesis | p. 215 |
| Proteomics--Direct Impact on Drug Discovery | p. 219 |
| Turning Discovery Into Cure | p. 220 |
| Automation Of Proteomics | p. 221 |
| Picks And Shovels Of Proteomics | p. 223 |
| 2D Gel Electrophoresis | p. 223 |
| Classification by Absorption | p. 224 |
| Emerging Approaches | p. 225 |
| Promise Of Antibody Microarray | p. 225 |
| Two Useful Twists In The Protein Junkyard | p. 226 |
| Paleontology Of Disease--Beyond Genomics And Proteomics | p. 228 |
| Omics This And Omics That | p. 229 |
| Directed Evolution | p. 230 |
| Submicron Technology And Nanotechnology | p. 235 |
| Midas! Gold In Potentia | p. 235 |
| From Alchemy To Algeny | p. 235 |
| Now Nanotechnology | p. 237 |
| Nano Research And Development | p. 238 |
| Self Assembly Versus Positional Assembly | p. 240 |
| Nature's Assembler | p. 242 |
| The Diamond of Living System--Stem Cell | p. 243 |
| A Caveat in Mimicking Nature | p. 244 |
| Drexler's Assemblers | p. 245 |
| Manipulations In Nanoscale | p. 247 |
| From Controlled Environment To Work Environment | p. 248 |
| From Algeny To Almoly | p. 249 |
| Biomimetics--The Confluence Of Biotechnology, And Nanotechnology | p. 251 |
| Nano Dragon | p. 251 |
| Patentability in Biotechnology | p. 253 |
| Decoding A Genetic Announcement | p. 253 |
| Enclosing The Genetic Commons | p. 254 |
| Europe | p. 254 |
| The Middle Kingdom | p. 256 |
| The New World--USA | p. 258 |
| The Final Frontier--Where No Life Scientists Have Gone Before | p. 261 |
| Biopatentability | p. 261 |
| Biopiracy And Biocolonialism | p. 262 |
| Cash Cows from Crops | p. 263 |
| Ethnobotany and Bioprospecting | p. 263 |
| Pirating Indigenous Knowledge | p. 264 |
| International Governing Bodies | p. 269 |
| Just Price | p. 270 |
| The Biotech Century | p. 270 |
| Who Owns What? | p. 272 |
| Biological and Biology-Related Information as a Commodity and the Rise of Bioinformatics | p. 273 |
| The Dynamic High Tech World | p. 273 |
| Types Of Focused Companies | p. 274 |
| Operationally Efficient Companies | p. 274 |
| Service-oriented Companies | p. 275 |
| Product-driven Companies | p. 276 |
| Biology And Biology-Related Disciplines--Place In Science | p. 276 |
| Pharmaceutical Companies As Product-Driven Companies | p. 277 |
| The Economics Of Drug Discovery | p. 279 |
| Future Pharmaceutical Discoveries | p. 280 |
| The Rise Of Bioinformatics | p. 281 |
| The Beginning | p. 282 |
| Subsequent Years | p. 284 |
| Bioinformatics Conference Going Commercial | p. 287 |
| Genomic Companies As Service-Oriented Companies | p. 287 |
| Bioinformatics--Mission and Goals | p. 289 |
| Bioinfobahn | p. 292 |
| A New Paradigm Of Discovery | p. 293 |
| Historical De Javu? | p. 294 |
| Turbo-Charging Bioinformation for Drug Discovery | p. 297 |
| From Gathering To Information Gathering | p. 297 |
| Information Economy | p. 297 |
| Drug Discovery | p. 298 |
| The Human Genome Project | p. 301 |
| Enabling Bioinformatics--The Enabler | p. 301 |
| Proliferation Of Bioinformatics | p. 303 |
| Market Structures | p. 303 |
| Perfect Competition | p. 304 |
| Monopoly | p. 304 |
| Monopolistic Competition | p. 304 |
| Oligopoly | p. 305 |
| Market Structures Of Bioinformatics, Sequencing, Biotechnology And Pharmaceutical Companies | p. 305 |
| Goals of Bioinformatics Companies to Monopolize | p. 306 |
| Competition | p. 308 |
| Bioinformatics Entrepreneurs And New Entrants | p. 308 |
| Bioinformatics Labor Supply | p. 309 |
| Technology-Push, Market-Pull Or Interactive Marketing Strategies | p. 311 |
| New Paradigm Adoption | p. 313 |
| Who Prevails | p. 314 |
| Short-run Profit/Loss Optimization | p. 314 |
| Long-run Economic Profits | p. 316 |
| Perfect Versus Monopolistic | p. 316 |
| Bioinformatics Gorillas, Chimpanzees And Monkeys | p. 317 |
| Early And Late Majority Asian Bioinformatics And Biotechnology Countries | p. 318 |
| Singapore--One of the Four Tigers | p. 318 |
| Korea--A Tiger | p. 319 |
| The Republic of China--A Tiger | p. 320 |
| Enter the Dragon--People's Republic of China | p. 322 |
| Rise with the Dragon | p. 323 |
| Asia and Pacific Rim Rising | p. 326 |
| Who Owns What? | p. 327 |
| Loopholes In Intellectual Property System | p. 327 |
| Brain Drain Or Gain? | p. 329 |
| A New Kind Of War: Biowarfare And Info Warfare | p. 331 |
| A New Kind Of War | p. 331 |
| United States Of Anxiety | p. 332 |
| High Tech, Low Tech And No Tech | p. 333 |
| Germ Warfare Agents | p. 333 |
| Aum Shinrikyo--Japanese Cult | p. 336 |
| Anthrax As Bioweapon | p. 337 |
| Smallpox--Eradicated but Not Gone for Good | p. 339 |
| Deadly Past in History--Smallpox | p. 339 |
| Countermeasures to Combat Bioterrorism | p. 341 |
| Anthrax Vaccines | p. 342 |
| Ciprofloxacin | p. 342 |
| Antimicrobial Nanoemulsion | p. 344 |
| Promises But Not Yet A Sure Cure | p. 345 |
| Hypothetical Bioterrorism | p. 345 |
| Protective Gear | p. 346 |
| Surveillance and Monitoring | p. 346 |
| Quick Counter Jabs | p. 348 |
| BTWC Treaty--Firm But Unfair | p. 349 |
| Forcing Genie Back Into The Bottle? | p. 351 |
| Cyber Warfare--A Keyboard Is Truly Mightier Than A Gun | p. 352 |
| The Mighty Electron | p. 353 |
| WWW--World Wide Weapon | p. 353 |
| The New Villain | p. 360 |
| He Who Lives in Glass Houses Should Throw No Stones | p. 363 |
| Friend or Foe? | p. 364 |
| What Is In Store? | p. 365 |
| Ongoing And Future Business Practice | p. 367 |
| Business Warfare | p. 367 |
| Business Cyber War | p. 368 |
| Ending Note | p. 370 |
| Two Decades of Biotechnology and a Decade of Bioinformatics | p. 371 |
| BT Meets IT | p. 371 |
| Technology Convergence | p. 372 |
| BT-IT Convergence | p. 373 |
| Moore's Law Says More's Less | p. 374 |
| The Internet--The Backbone of BT-IT Convergence | p. 375 |
| Computers In Discovery Processes | p. 376 |
| Challenges Of BT-IT Convergence | p. 378 |
| Bioinformaticist Dearth | p. 378 |
| Bioinformatics Gorillas, Chimpanzees and Monkeys | p. 378 |
| Opening up a Framework | p. 379 |
| Creating a Language out of ATCG | p. 380 |
| All The Fuss, Where Is The Beef? | p. 382 |
| Information and Knowledge: Factors of Production | p. 383 |
| Technology, Markets, and Competition | p. 384 |
| The River Of Change | p. 385 |
| Capability and Copability on the River of Change | p. 386 |
| An Effective, Intelligent And Responsible Generalist With A Specialty | p. 386 |
| The Gentlemen And The Technologist | p. 388 |
| From Classroom to Boardroom and Vice Versa | p. 390 |
| Smart Work, Hard Work and Hyper Work | p. 392 |
| Training And Education | p. 393 |
| Above, At, Within the Laws | p. 395 |
| History Of Science On Trial | p. 396 |
| Case Closed And The Future Is Rosy | p. 399 |
| Index | p. 401 |
| Table of Contents provided by Ingram. All Rights Reserved. |
ISBN: 9789810249380
ISBN-10: 9810249381
Published: 4th April 2002
Format: Hardcover
Language: English
Number of Pages: 440
Audience: General Adult
Publisher: World Scientific Publishing Co Pte Ltd
Country of Publication: SG
Dimensions (cm): 23.5 x 16.51 x 3.18
Weight (kg): 0.77
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