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Genetically Engineered Vaccines

By: J.E. Ciardi (Editor)

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Hardcover

At a Glance

Hardcover
342 Pages

Dimensions(cm)
18.6 x 26.3 x 2.5

Hardcover

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Proceedings of a National Institute of Dental Research workshop held in November, 1991, in Bethesda, Maryland. While exploring the development of vaccines in the prevention of oral diseases, the papers address three key areas: optimizing the mucosal immune response; possible antigen delivery systems

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You Can Find This Book In

Non-Fiction Science Biology, Life Sciences Life Sciences in General Genetics excluding Medical Medicine Clinical & Internal Medicine Otorhinolaryngology ENT Diseases & Disorders Immunology Other Branches of Medicine Pharmacology

Pathology Medical Microbiology & Virology Infectious & Contagious Diseases Ecological Science Botany & Plant Sciences Zoology & Animal Sciences

Introductory Address
The New Biology and Vaccine Research	p. 1
Keynote Presentation
Mucosal Immunity to Vaccines: Current Concepts for Vaccine Development and Immune Response Analysis	p. 3
Oral Diseases and Host Immune Responses
Prospects for Human Mucosal Vaccines	p. 13
Bacterial Diseases of the Oral Tissues	p. 25
Oral Virus Infections: The Potential for Gene Transfer in Treatment and Prevention	p. 35
Update on Vaccines and Vaccine Development
Bacterial Mucosal Vaccines	p. 43
A General Overview of Viral Vaccine Development	p. 51
Vaccines and the Mucosal Immune System
An Update on the "Jennerian" And Modified "Jennerian" Approach to Vaccination of Infants and Young Children Against Rotavirus Diarrhea	p. 59
Induction of Mucosal and Serum Immune Responses to a Specific Antigen of Periodontal Bacteria	p. 71
IgA1 Proteases and Host-Parasite Relationships in the Oral Cavity	p. 83
Transport of IgA Immune Complexes Across Epithelial Membranes: New Concepts in Mucosal Immunity	p. 91
Effect of Mucosal Microenvironment on Immune Response to Viruses	p. 95
Optimizing Mucosal and Systemic Immune Responses
Induction of T Helper Cells and Cytokines for Mucosal IgA Responses	p. 107
Cytokine Production and T Cell Receptor Expression by Salivary Gland T Cells and Intraepithelial T Lymphocytes for the Regulation of the IgA Response	p. 119
Immunological Adjuvants	p. 133
Delivery Systems and Immune Analysis
Passive Immunity
M Cell-Mediated Antigen Transport and Monoclonal IgA Antibodies for Mucosal Immune Protection	p. 143
A Mechanism of Passive Immunization with Monoclonal Antibodies to a 185,000 M[subscript r] Streptococcal Antigen	p. 151
Active Immunity
Delivery of Antigens by Recombinant Avirulent Salmonella Strains	p. 165
Use of Recombinant BCG as a Vaccine Delivery Vehicle	p. 175
Vaccinia Virus Recombinants as Potential Herpes Simplex Virus Vaccines	p. 183
Liposomes and Conjugate Vaccines for Antigen Delivery and Induction of Mucosal Immune Responses	p. 191
Peroral Immunization With a Cholera Toxin-Linked Bacterial Protein Antigen and Synthetic Peptide	p. 199
Peptomers as Vaccine Candidates	p. 209
Target Antigen Selection and Vaccine Development
Structural and Functional Studies of Herpes Simplex Virus Glycoprotein D	p. 217
Molecular, Immunological and Functional Characterization of the Major Surface Adhesin of Streptococcus Mutans	p. 229
Reactive Antigens of the Periodontopathic Bacterium Actinobacillus Actinomycetemcomitans	p. 243
Immunization With Fimbrial Protein and Peptide Protects Against Porphyromonas Gingivalis-Induced Periodontal Tissue Destruction	p. 255
Vaccine Development: Progression from Target Antigen to Product	p. 263
Immunological Correlates of Protection
Significance of Immune Responses to Oral Antigens in Dental Diseases	p. 273
Laboratory Correlates of Protection and Protective Immunity to Bordetella Pertussis	p. 287
Future Directions
Challenges and Opportunities in Vaccine Research	p. 293
Summary and Recommendations for Future Research	p. 301
Speakers and Moderators	p. 315
Author Index	p. 319
Subject Index	p. 321
Table of Contents provided by Blackwell. All Rights Reserved.

Genetically Engineered Vaccines

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Hardcover

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