| Preface | p. xi |
| Fibrous Proteins: New Structural and Functional Aspects Revealed | |
| Introduction | p. 2 |
| [alpha]-Fibrous Proteins | p. 2 |
| Connective Tissue | p. 6 |
| Summary | p. 9 |
| Structural and Functional Implications of Sequence Repeats in Fibrous Proteins | |
| Introduction | p. 12 |
| Sequence Regularities | p. 13 |
| Effect of Sequence Repeats on Secondary Structure, and Implications for Tertiary and Quaternary Structure | p. 15 |
| Summary | p. 30 |
| References | p. 32 |
| The Structure of [alpha]-Helical Coiled Coils | |
| Historical Introduction | p. 37 |
| Structural Parameters | p. 40 |
| Structural Determinants of Folding and Stability | p. 56 |
| Structural Diversity | p. 60 |
| Function Follows Structure | p. 70 |
| References | p. 72 |
| The Design of Coiled-Coil Structures and Assemblies | |
| Introduction to Protein Design | p. 80 |
| Rules for Coiled-Coil Design: The Basics of Coiled-Coil Sequence and Structure | p. 82 |
| Key Coiled-Coil Designs | p. 92 |
| Summary | p. 105 |
| References | p. 106 |
| Microdissection of the Sequence and Structure of Intermediate Filament Chains | |
| Introduction | p. 114 |
| Sequence Regularities and Characteristics, and Their Effects on Secondary and Tertiary Structure | p. 116 |
| Summary | p. 136 |
| References | p. 137 |
| Intermediate Filament Associated Proteins | |
| Introduction | p. 144 |
| Plakin Family | p. 146 |
| Cell Surface-IF Interactions | p. 159 |
| Other Crosslinkers not in the Plakin Family | p. 168 |
| IFAPs as Participants in a Signaling Scaffold and Cellular Metabolism | p. 173 |
| Motors that Move IFs | p. 178 |
| The Fine Line between IFs and IFAPs | p. 180 |
| Conclusions and Future Directions | p. 181 |
| References | p. 182 |
| Spectrin, [alpha]-Actinin, and Dystrophin | |
| Introduction | p. 204 |
| Evolution | p. 205 |
| Structure | p. 208 |
| Function | p. 210 |
| Regulations of Interactions | p. 221 |
| Disease | p. 227 |
| Conclusions | p. 232 |
| References | p. 233 |
| Fibrinogen and Fibrin | |
| Introduction | p. 248 |
| Structure and Properties of Fibrinogen | p. 251 |
| Biosynthesis and Metabolism of Fibrinogen | p. 260 |
| Conversion of Fibrinogen to Fibrin | p. 263 |
| Binding of Other Proteins to Fibrin (ogen) | p. 273 |
| Fibrinolysis | p. 275 |
| Fibrinogen Binding to Integrins in Platelet Aggregation and Other Cellular Interactions | p. 277 |
| Dysfibrinogenemias, Variants, and Heterogeneity of Fibrinogen | p. 279 |
| Evolution of Fibrinogen and Fibrinogen-Like Domains | p. 283 |
| Conclusions | p. 284 |
| References | p. 285 |
| Molecular Structure of the Collagen Triple Helix | |
| Introduction | p. 302 |
| The Biological Role and Occurrence of the Collagen Triple-Helix Motif in Proteins | p. 303 |
| Molecular Structure: Collagen and Collagen Model Peptides | p. 307 |
| Mechanism of Hydroxyproline Stabilization | p. 319 |
| Breaks in the Gly-X-Y Repeating Pattern | p. 323 |
| Amino Acid Sequence and Stability | p. 323 |
| Ligand Binding | p. 326 |
| Mutations and Disease | p. 329 |
| Conclusions | p. 332 |
| Abbreviations and Notation | p. 332 |
| References | p. 333 |
| Collagen Fibril Form and Function | |
| Introduction | p. 342 |
| The Collagens that Constitute Fibrils | p. 342 |
| Fibrillar Molecular Packing | p. 345 |
| Lateral Packing in Fibrillar Collagens | p. 350 |
| Novel Fibrillar Structures | p. 354 |
| Subfibrillar Structures | p. 356 |
| Fibril Surface | p. 356 |
| Factors that May Regulate Fibril Growth and Size | p. 357 |
| Distribution of Fibril Sizes | p. 359 |
| Suprafibrillar Architectures | p. 361 |
| Mechnical Properties of Collagen-Rich Tissue | p. 365 |
| Conclusions | p. 366 |
| References | p. 367 |
| Molecular Packing in Network-Forming Collagens | |
| Introduction | p. 375 |
| Network-Forming Collagens in Detail | p. 377 |
| Intertwining of Network Collagens: The Type VI Segmented Supercoil | p. 392 |
| Common Structural Themes in Network-forming Collagens | p. 396 |
| References | p. 399 |
| Fibrillin Microfibrils | |
| Introduction | p. 406 |
| Fibrillin Molecules | p. 406 |
| Fibrillin Assembly | p. 412 |
| Microfibril Organization and Elasticity | p. 417 |
| Fibrillin-1 Alignment Models | p. 420 |
| Fibrillin Microfibrils in Aging and Disease | p. 426 |
| Summary | p. 429 |
| References | p. 429 |
| Elastin | |
| Elastic Fiber | p. 438 |
| Elastogenesis | p. 440 |
| Properties of Elastin | p. 446 |
| Mechanism of Elasticity | p. 449 |
| Biomaterials | p. 450 |
| References | p. 453 |
| Author Index | p. 463 |
| Subject Index | p. 507 |
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