Epigenetics and Systems Biology

I. Instability of RNA and DNA viruses II. Bacterial genome instability: 1. General strategies for maintaining genome stability 2. MMR 3. GATC methylation/restriction 4. CRISPR III. Genome instability of unicellular simple eukaryotes 5. Genome instability of ciliates 6. Genome stability in yeasts 7. Genome stability in fungi IV. Genome stability in invertebrate animals 8. Genome stability in Drosophila 9. Genome stability in C. elegans V. Plant genome stability VI. Genome stability in mammals 10. Chromatin and nuclear organization and genome stability 11. Cell cycle control and DNA damage signalling 12. Replication and postreplication repair 13. BER/NER 14. MMR 15. DSB repair - NHEJ and HR VII. Specific mechanisms of DNA damage signaling and repair 16. H2AX 17. ATM1 signalling 18. Role of p53/p16/p22 19. Mitotic catastrophe VIII. Human diseases associated with genome instability 20. Genetic diseases - Xeroderma Pigmentosum, Cockayne syndrome, Fanconi Anemia, Njemigan breakage syndrome 21. Cancer 22. Cancer and genome instability 23. The epigenetic regulation of cell cycle and DNA repair in cancer IX. Aging and genome instability X. The effect of environment and genome stability 24. Diet and nutrition 25. Chemical mutagenesis 26. Radiation and DNA damage XI. Bystander and transgenerational effects 27. Epigenetics of transgenerational genome instability in mammals 28. Bystander effects in genome instability 29. Transgenerational genome instability in plants