Developments in Cardiovascular Medicine

By: Killian Robinson (Editor), K. Robinson (Editor)

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Hardcover | 30 April 2000

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476 Pages

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24.13 x 16.51 x 2.54

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This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.

Industry Reviews

`The book is therefore a great reference for an up-to-date review of any one of the many pathways involved in homocysteine metabolism. The editor should be applauded for bringing together some of the leaders in the field of homocysteine research and thus compiling a comprehensive review that should be on the shelf of any scientist working in the area of homocysteine.'
Clinical Chemistry, 47:6 (2001)

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Non-Fiction Science Biology, Life Sciences Medicine Clinical & Internal Medicine Cardiovascular Medicine Medicine in General Medical Equipment & Techniques Medical Research

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Published: 4th December 2010

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Foreword
Editor's Historical
Preface
List of Contributors
Note on Nomenclature
Dedication
Introduction
Historical Aspects of the Relationship Between Homocysteine and Vascular Disease
Biochemistry and Metabolism
Reference Ranges for Homocysteine Concentrations
Determinants of Plasma Homocysteine
Epidemiology of Homocysteine Levels and Relation to Vitamins
Vascular Pathology of Hyperhomocysteinemia
Vascular Complications of Homocystinuria: Incidence, Clinical Pattern and Treatment
Homocysteine as a Risk Factor for Peripheral Vascular Disease
Homocysteine as a Risk Factor for Cerebrovascular Disease and Stroke
Homocysteine as a Risk Factor for Coronary Artery Disease
Homocysteine and Family History of Coronary Artery Disease
Homocysteine as a Risk Factor for Cardiovascular Disease in Women
Homocysteine and Venous Thrombosis
Homocysteine and Renal Disease
Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR): Interrelationships with Folic Acid, Homocysteine and Vascular Disease
Molecular Biology of Methionine Synthase: Interrelationships with Homocysteine and Vascular Disease
Molecular Biology of Cystathionine bgr;-Synthase Interrelationships with Homocysteine, Pyridoxine, and Vascular Disease
Homocysteine and Cholesterol: Basic and Clinical Interactions
Homocysteine and Coagulation Factors: Basic Interactions and Clinical Studies
Homocysteine and Endothelial Dysfunction
The Treatment of High Homocysteine Concentrations in Homocystinuria: Biochemical Control in Patients and their Vascular Outcome
An Overview of the Homocysteine Lowering Clinical Trials
Summary and Future Directions for Epidemiological, Preventive and Basic Research
Index
Table of Contents provided by Publisher. All Rights Reserved.

Developments in Cardiovascular Medicine

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

Other Editions and Formats

Paperback

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