Handbook of Experimental Pharmacology

An Approach to Disease Models

By: Robert Feil, Daniel Metzger (Editor)

Write A Review

Hardcover | 28 November 2006

At a Glance

Hardcover
544 Pages

Dimensions(cm)
23.5 x 15.88 x 2.54

Hardcover

$489.01

or 4 interest-free payments of $122.25 with

Ships in 5 to 7 business days

Leading experts provide timely and comprehensive information on methods for conditional mutagenesis in the mouse (part 1) and their application to model human physiology and pathophysiology (part 2). It illustrates how sophisticated genetic manipulations of the mouse genome are employed to model human diseases and to identify underlying molecular mechanisms. Finally the book considers the development of new drugs to treat them.

Industry Reviews

From the reviews:

"This is a comprehensive overview of generating mouse models with conditional modification of genes to study the effects of gene dysfunction in the development of human diseases. ... The authors target general scientific researchers ... . This book will be very informative for any scientists and students interested in using or generating genetically modified mouse models in biomedical research. ... an excellent reference on the most recent progress in generating conditional knockout mice." (Grace L Guo, Doody's Review Service, July, 2008)

Shipping

	Standard Shipping	Express Shipping
Metro postcodes:	$9.99	$14.95
Regional postcodes:	$9.99	$14.95
Rural postcodes:	$9.99	$14.95

Orders over $89.00 qualify for free shipping.

How to return your order

At Booktopia, we offer hassle-free returns in accordance with our returns policy. If you wish to return an item, please get in touch with Booktopia Customer Care.

Additional postage charges may be applicable.

Defective items

If there is a problem with any of the items received for your order then the Booktopia Customer Care team is ready to assist you.

For more info please visit our Help Centre.

Tools for Conditional Mutagenesis
Conditional Somatic Mutagenesis in the Mouse Using Site-Specific Recombinases	p. 3
Cre/loxP-Mediated Chromosome Engineering of the Mouse Genome	p. 29
Tetracycline-Controlled Genetic Switches	p. 49
Novel Gene Switches	p. 73
Improved Embryonic Stem Cell Technologies	p. 107
Gene Trap Mutagenesis	p. 129
RNA Interference in Mice	p. 149
Viral Vectors: A Wide Range of Choices and High Levels of Service	p. 177
Conditional Mutagenesis by Cell-Permeable Proteins: Potential, Limitations and Prospects	p. 203
Examples of Conditional Disease Models
Analysis of Mouse Development with Conditional Mutagenesis	p. 235
Conditional Mouse Models of Cancer	p. 263
Conditional Mutagenesis Reveals Immunological Functions of Widely Expressed Genes: Activation Thresholds, Homeostatic Mechanisms and Disease Models	p. 289
Conditional Transgenesis and Recombination to Study the Molecular Mechanisms of Brain Plasticity and Memory	p. 315
A Novel Conditional Knockout Strategy Applied to Serotonin Receptors	p. 347
Conditional Mouse Models for Friedreich Ataxia, a Neurodegenerative Disorder Associating Cardiomyopathy	p. 365
Animal Models in Cardiovascular Diseases: New Insights from Conditional Models	p. 377
Conditional Animal Models for the Study of Lipid Metabolism and Lipid Disorders	p. 407
Conditional Mouse Models to Study Developmental and Pathophysiological Gene Function in Muscle	p. 441
Analysis of Calcium Channels by Conditional Mutagenesis	p. 469
Conditional Mutagenesis of G-Protein Coupled Receptors and G-Proteins	p. 491
Contribution of Targeted Conditional Somatic Mutagenesis to Deciphering Retinoid X Receptor Functions and to Generating Mouse Models of Human Diseases	p. 511
Subject Index	p. 525
Table of Contents provided by Publisher. All Rights Reserved.

Handbook of Experimental Pharmacology

An Approach to Disease Models

At a Glance

Hardcover

Industry Reviews

Shipping

How to return your order

Defective items

You Can Find This Book In

More in Biochemistry

Protein in 15

Easy, tasty, unprocessed meals for everyone by The Body Coach

Lehninger Principles of Biochemistry 8th edition

International Edition

Chemistry for the Biosciences

4th Edition - The Essential Concepts

Easy Keto Meal Prep

Simplify Your Keto Diet with 8 Weekly Meal Plans and More than 60 Recipes

Biochemistry

Transition Metal-Based Layered Double Hydroxides

Chemistry and Applications

Biomimicry - A Functional Approach

Biologically-Inspired Systems

Enhancing Adolescent Health

The Contribution of Exercise to Growth and Metabolism

Campbell Biology, Australian and New Zealand Edition + Mastering Biology with Pearson eText

Nectaries and Nectar

Nutrition for Sport, Exercise, and Performance

2nd Edition - Science and Application

V Is for Venom

Agatha Christie's Chemicals of Death

Linear Algebra: A Modern Introduction

4th Edition

Introduction to Research in the Health Sciences

7th Edition

Cancer as a Metabolic Disease

On the Origin, Management, and Prevention of Cancer

Biochemistry For Dummies

For Dummies

Smarter Not Harder

The Biohacker's Guide to Getting The Body and Mind You Want

Pihkal : A Chemical Love Story

A Chemical Love Story

Marks' Basic Medical Biochemistry

6th Edition - A Clinical Approach

Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology

8th edition

Principles of Biochemistry

5th Edition - Pearson New International Edition

Medical Biochemistry

6th Edition

The Color of North

The Molecular Language of Proteins and the Future of Life

Rainbow and the Worm, The

The Physics of Organisms (3rd Edition)

This product is categorised by