Computer Applications in Fermentation Technology

1: Measurement.- Integrated fermentor sampling and analysis.- Measurement of biological reaction rates using advanced pH control systems.- Morphological measurements on filamentous microorganisms by image analysis.- Reconciliation of measurement data in fermentation using on-line expert system.- Glucose biosensors for the study and control of bakers compressed yeast production.- Computer controlled system for on-line monitoring of a fermentation process.- 2: Modelling I.- Structured modelling of bioreactor systems.- Mathematical simulation of anaerobic stratified biofilm processes.- A new approach for development of structured growth models.- Modelling secondary metabolite production - case pleuromulin.- Modelling of kinetics, mass transfer and mixing phenomena in 45, 450 and 4500 L tank fermenters.- A software tool for fermentation modelling.- Hydrodynamic and kinetic modelling of a flocculating bioreactor with cell recycle.- Modelling and simulation of naphthalene to salicylic acid fermentation process.- 3: Modelling II - System Identification, Parmeter and State Estimation.- An introduction to system identification, parameter and state estimation.- Expert system approach to recognize the state of fermentation and to diagnose faults in bioreactors.- Toward a systematic method for the generalization of fermentation data.- Adaptive inferential estimation and its application to biomass control.- Experimental validation of a methodology for on-line state estimation in bioreactors.- Optimal feeding strategy for identification of Monod-type models by fed-batch experiments.- Identification of a simulated continuous yeast fermentation.- Structured modelling and parameter identification of budding yeast populations.- Parameter estimation of kinetics and modelling in methanogenic fermentation of Methanosarcina barkeri.- On-line estimation of cell mass using an extended Kalman filter.- Observability by pH in bioprocesses.- 4: Control I.- Process controlled temperature induction during batch fermentations for recombinant DNA products.- Application of an expert system to the operation and control of industrial antibiotic fermentation process.- IBE fermentation control.- Improvement of the penicillin production in bench-scale reactors by on-line measurement, data evaluation and parameter-adaptive control.- On-line parameter identification and computer control of an anaerobic waste water treatment process.- On experiences with expert systems in the control of bioreactors.- Intelligent purification of monoclonal antibodies.- 5: Control II.- A fed-batch process for pullulanase production.- A new approach for the control of baker's yeast fed-batch fermentation.- Lyapunov design of convergent adaptive controllers for a class of multilinear systems arising from biotechnological applications.- A new nonlinear adaptive approach to automatic control of bioprocesses.- Adaptive algorithm for estimation and control of fed-batch bioprocesses.- Modelling and control of polygalacturonase production from Kluyveromyces marxianus.- Nonlinear estimation and adaptive control of a fed-batch fermentor.- Sensitivity analysis in static optimization of fermentation plants.- Maximum production of glutathione in fed-batch culture of Saccharomyces cerevisiae.- 6: Data Management.- Management of process control data for bio-process analysis.- Data handling for fermentation development - an industrial approach.- On-line monitoring of the response of a fermentation process to nutrient additions.- A modelling approach to trouble diagnosis by multilevel fuzzy functions and its application.- Model based optimization of a SCP fermentation process.- Adaptive monitoring of bioreactor contamination.- PC-based on-line estimation of derived variables.- The use of carbon dioxide evolution rate in consistency checking other fermenter sensor outputs.- Using the downhill Simplex method to fit complex rate equations to data.- Fermentation fault diagnosis using analytical redundancy.- Author Index.