Computational Biology

The authors present in this book a new general approach called parameter advising for finding a parameter setting that produces a high-quality alignment for a given set of input sequences. In this framework, a parameter advisor is a procedure that automatically chooses a parameter setting for the input, and has two main ingredients: (1) the set of parameter choices considered by the advisor, and (2) an estimator of alignment accuracy used to rank alignments produced by the aligner are covered in this book. On coupling a parameter advisor with an aligner, once the advisor is trained in a learning phase, the user simply inputs sequences to align, and receives an output alignment from the aligner, where the advisor has automatically selected the parameter setting.This book also examines formulations of parameter advising and their computational complexity, develops methods for learning good accuracy estimators, presents approximation algorithms for finding good sets of parameter choices, and assesses software implementations of advising that perform well on real biological data. It explores applications of parameter advising to adaptive local realignment, where advising is performed on local regions of the sequences to automatically adapt to varying mutation rates; and ensemble alignment, where advising is applied to an ensemble of aligners to effectively yield a new aligner of higher quality than the individual aligners in the ensemble. Finally, future directions in advising research are offered. Bioinformatics researchers in the area of sequence alignment, as well as researchers and practitioners working in discrete algorithms and machine learning seeking new research topics, and topic areas where the available computational methods have multiple parameters that must be tuned (such as computational modeling in engineering and the physical sciences), will find this book useful as a reference. Advanced-level students studying computer science and engineering will also find this book useful as a secondary text.