Biologic Knee Reconstruction

Dedication Acknowledgments About the Editors Contributing Authors Foreword by Lars Peterson, MD, PhD Section I Introduction Chapter 1 Articular Cartilage and Subchondral Bone Anatomy and PhysiologyJason J. Shin, MD; Adam B. Yanke, MD; and Nikhil N. Verma, MD Chapter 2 Articular Cartilage and Subchondral Bone PathologyBrian Chilelli, MD; Gloria Matthews, DVM, PhD; Tom Minas, MD; and Andreas H. Gomoll, MD Chapter 3 Patient Evaluation: History and Physical ExaminationMichael B. Ellman, MD and Charles A. Bush-Joseph, MD Chapter 4 Preoperative Articular Cartilage and Subchondral Bone ImagingAmit Gupta, MD; Michael C. Forney, MD; and Carl S. Winalski, MD Chapter 5 Postoperative Articular Cartilage and Subchondral Bone ImagingMichael C. Forney, MD; Amit Gupta, MD; and Carl S. Winalski, MD Chapter 6 Biomarkers in Early and Post-Traumatic OsteoarthritisAriel M. Bodker, MD; Christian Lattermann, MD; and Susan Chubinskaya, PhD Chapter 7 Chondral and Osteochondral Defect ClassificationJonathan M. Frank, MD and Bernard R. Bach Jr, MD Chapter 8 Patient- and Surgeon-Reported Outcomes AssessmentBrandon Beamer, MD and Frank McCormick, MD Section II Nonsurgical Treatment Chapter 9 Pharmacological TreatmentsJulia Bruene, MD and Kathleen Weber, MD, MS Chapter 10 Rehabilitation and PhysiotherapyBrandon Johnson, MD and Bert R. Mandelbaum, MD, DHL (Hon) Section III Cartilage Palliation Techniques Chapter 11 Debridement and Chondroplasty for Focal Chondral DefectsSanjeev Bhatia, MD; Rachel M. Frank, MD; and Brian Forsythe, MD Section IV Cartilage Repair Techniques Chapter 12 Subchondral Bone TreatmentGeoffrey D. Abrams, MD; Joshua D. Harris, MD; and Brian J. Cole, MD, MBA Chapter 13 Internal Fixation for Chondral and Osteochondral LesionsRyan J. McNeilan, MD; David C. Flanigan, MD; and Kyle Randall, MD Chapter 14 Microfracture, Nanofracture, PowerPick, and Abrasion ArthroplastyEthan Kellum, MD, MS and Kai Mithoefer, MD Chapter 15 Enhanced Marrow-Stimulation TechniquesRachel M. Frank, MD; Kai Mithoefer, MD; Sanjeev Bhatia, MD; and Brian J. Cole, MD, MBA Section V Cartilage Restoration Techniques: Cell-Based Therapies Chapter 16 Osteochondral AutograftAdam S. Wilson, MD and Mark D. Miller, MD Chapter 17 Fresh Osteochondral AllograftJoshua D. Harris, MD and Brian J. Cole, MD, MBA Chapter 18 Autologous Chondrocyte ImplantationAndreas H. Gomoll, MD Chapter 19 Other Chondrocyte-Based Cell TherapiesGiuseppe Filardo, MD, PhD; Luca Andriolo, MD; Elizaveta Kon, MD; and Maurilio Marcacci, MD, Prof Chapter 20 Stem Cell-Based Cell Therapies 1Elizaveta Kon, MD; Alice Roffi, BSc; Giuseppe Filardo, MD, PhD; and Maurilio Marcacci, MD, Prof Section VI Combined Techniques: Biologic Knee Reconstruction Chapter 21 Malalignment—Varus—High Tibial OsteotomyFrancesca de Caro, MD and Annunziato Amendola, MD Chapter 22 Malalignment—Valgus—Distal Femoral OsteotomyGregory A. Sawyer, MD and Robert F. LaPrade, MD, PhD Chapter 23 Proximal and Distal Patellofemoral SurgeryJack Farr, MD and Andreas H. Gomoll, MD Chapter 24 Meniscal Deficiency: Repair and TransplantationPeter N. Chalmers, MD; Robert A. Sershon, MD; and Brian J. Cole, MD, MBA Section VII The Future of Articular Cartilage Surgery Chapter 25 Costs and Research Funding: Public and Private SourcesGeoffrey S. Van Thiel, MD, MBA and Brian J. Cole, MD, MBA Chapter 26 Governmental Regulation and Availability and Accessibility to PatientsJonathan A. Godin, MD, MBA and Richard C. Mather III, MD, MBA Chapter 27 Barriers to High-Quality Randomized Trials: Noninferiority to SuperiorityJaskarndip Chahal, MD, MSc, FRCSC and Ken Zaslav, MD Chapter 28 Gene Therapy and Tissue EngineeringLaurie R. Goodrich, DVM, PhD, Diplomate ACVS Chapter 29 Ethics of Articular Cartilage Surgery: Stem Cells, Ex Vivo Manipulation, and Juvenile SourcesH. Davis Adkisson, PhD; Philip R. Streeter, PhD; Kevin F. Bonner, MD; and Joseph Feder, PhD Financial Disclosures Index