Basic Life Sciences

Section I. Introduction.- Molecular Mechanisms in Genetic Stability and Change: The Role of Deoxyribonucleotide Pool Balance.- Section II. Nucleotide Metabolism.- Metabolic Effects of Poly(ADP-ribose) Inhibitors.- Ribonucleotide Reductase and Deoxyribonucleotide Pools.- Enzymatic Channeling of DNA Precursors.- A Possible Secondary Role for Thymine-Containing DNA Precursors.- Multiple Mechanisms of Adenosine Toxicity in an Adenosine Sensitive Mutant of Baby Hamster Kidney (BHK) Cells.- Section III. DNA Replication Errors Caused by Nucelotide Imbalance.- Effects of Altered Nucleotide Concentrations on the Fidelity of DNA Replication.- Response of CHO Cell DNA Polymerase Alpha to dCTP and dTTP Pool Imbalance: Relation to DNA Synthesis Inhibition, Survival, and Mutation.- Misincorporation of Deoxyuridine in Human Cells: Consequences of Antifolate Exposure.- Effects of Nucleotide Pool Imbalances on the Excision Repair of Ultraviolet-Induced Damage in the DNA of Human Diploid Fibroblasts.- Effect of Variations in the Conditions of DNA Synthesis Upon the Accuracy of DNA Replication.- Section IV. Genetic Consequences of Nucleotide Pool Imbalances.- Thymineless Mutagenesis in Bacteria.- Genetic and Biochemical Effects of Thymidylate Stress in Yeast.- Biological Consequences of Guanine Starvation.- Thymineless Death and Genetic Events in Mammalian Cells.- Induction of Mitochondrial Mutations in Human Cells by Methotrexate.- Induction of Mutation and Chromosome Damage by Excess Bases and Nucleosides.- The Genetic Consequences of the Thy? Mutation to CHO Cells.- Deoxyribonucleoside-Induced Selective Modulation of Cytotoxicity and Mutagenesis.- Section V. Base Analog and Nucleotide Mutagenesis.- Viewing the Complexities of Mutagenesis from an Evolutionary Perspective.- Mutagenesis by Incorporation of Alkylated Nucleotides.- 2-Aminopurine Mutagenesis in Escherichia coli.- Mutagenicity of 2-Aminopurine, 6-N-Hydroxylaminopurine and 2-Amino-N6-Hydroxyadenine in Neurospora crassa.- Bromodeoxyuridine Mutagenesis and Deoxyribonucleotide Pool Imbalance in Mammalian Cells.- The Biochemical Basis of 5-Bromouracil - and 2-Aminopurine-Induced Mutagenesis.- Mutation Induction by Excess Deoxyribonucleotides in Saccharomyces cerevisiae.- The Effects of Pyrimidine Nucleotides on Alkylating Agent Induced Cytotoxicity and Spontaneous and Induced Mutation to Purine Analog Resistance in V79 Cells.- Section VI. Biological Implications of Nucleotide Pool Imbalances.- Aspects of DNA Repair and Nucleotide Pool Imbalance.- Agents Which Decrease Intracellular Thymidine Pools Cause an Augmentation in Human Natural Killer Activity in vitro.- Oncogenic Transformation of C3H/10T1/2 Cl 8 Mouse Embryo Fibroblasts by Inhibitors of Nucleotide Metabolism.- Regulation of Extracellular Thymidine Pools in Human Blood Samples.- Purine Nucleotide Imbalance in Immunodeficiency Disorders.- Contributors.