Antisense Elements (Genetics) Research Focus

By: A G Hernandes (Editor)

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226 Pages

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Antisense molecules interact with complementary strands of nucleic acids, modifying expression of genes. Some regions within a double strand of DNA code for genes, which are usually instructions specifying the order of amino acids in a protein along with regulatory sequences, splicing sites, non-coding introns and other complicating details. For a cell to use this information, one strand of the DNA serves as a template for the synthesis of a complementary strand of RNA. The template DNA strand is called the transcribed strand with antisense sequence and the mRNA transcript is said to be sense sequence (the complement of antisense). Because the DNA is double-stranded, the strand complementary to the antisense sequence is called non-transcribed strand and has the same sense sequence as the mRNA transcript (though T bases in DNA are substituted with U bases in RNA). This book presents important new research from around the world in this field.

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Non-Fiction Science Chemistry Organic Chemistry Biology, Life Sciences Biochemistry Medicine Pre-Clinical Medicine & Basic Sciences Medical Genetics

Clinical Application of RNAi: Novel Strategies for Cancer Therapy	p. 1
Natural Grp78 Antisense RNA Induces Apoptosis by Creating a Chimeric mRNA with Msh4 pre-mRNA	p. 27
Selection of Target Sites in RNA for Antisense Agents	p. 71
Silencing the Brain by RNA Interference: A Promising Approach for Therapeutic Use	p. 91
Natural Antisense RNA in Mammals: New Characteristics Revealed by Recent Genome-Wide Expression Analysis	p. 109
Sequence Requirements for Effective Mammalian RNAi Induced by Short Double-Stranded RNAs Equal to or More than 22bp in Length	p. 141
Effects of Anti-K-Ras and Anti-Telomerase Phosphorothioate Antisense Oligodeoxynucleotides on Colorectal Cancer Growth	p. 161
Antisense Strategy, Targeting for Microtubule-Associated Protein and other Proteins in Glioma Cells	p. 179
Oligodeoxynucleotide Expression Library for Discovery of Novel Antibiotics	p. 199
Index	p. 213
Table of Contents provided by Blackwell. All Rights Reserved.

Antisense Elements (Genetics) Research Focus

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Hardcover

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