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Antibiotics : Current Innovations and Future Trends - Sergio Sanchez

Antibiotics

Current Innovations and Future Trends

By: Sergio Sanchez (Editor), Arnold L Demain (Editor)

Hardcover | 1 January 2015

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The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in human- and animal-health and the associated dramatic increase in human life expectancies. Indeed, the possibility of eradicating infectious disease seemed feasible. However, it soon became apparent that microorganisms wouldn't be defeated so easily. Their weapon: antibiotic resistance. Today, microbial antibiotic resistance is rapidly exhausting the supply of effective compounds, and this makes the possibility of a global public health disaster seem likely. The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents. In this timely book, respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic,' explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. The book will be essential reading for everyone working in antimicrobial research, biotechnology companies, and the pharmaceutical industry, and it is recommended for all microbiology libraries. [Subject: Microbiology, Life Science, Medicine]
Industry Reviews

"a useful resource for anyone involved in that research as well as biotechnology companies and the pharmaceutical industry" from Book News (Dec 2014)

"The timing is absolutely perfect for the publication of this informative and inspirational collection of articles on antibiotics. One would expect no less from Arnold Demain, for long one of the world's leading microbiologists, ably assisted by Sergio Sanchez. The book is remarkably good value due to the breadth of the articles, which range from historical perspectives on antibiotics, through to perspectives on the current state of the art in antibiotic drug discovery, antimicrobial resistance and perspectives on the reasons for lack of new antibiotics in recent decades. The book is genuinely a brilliant resource ... Overall this is an absolutely excellent book on antibiotics - almost every chapter has something of interest for researchers in the field and provides an outstanding overview of very widespread interest. " fromChemMedChem (2015) 925-928.

"packed full of useful information ... information which is difficult to find elsewhere ... I found the book informative and easy to read, and the scope is huge with a lot of coverage given to the new sources of antibiotics ... I recommend this book as an essential reference for anyone interested in the field of antimicrobial resistance and antibiotic discovery" fromMicrobiology Today (2015) 42: 86.

"...an updated overview of the field ... insightful reading ..." from BIOspektrum (2015) 21: 356-357.

"This text book is a structured compilation of scholarly papers ... vast amounts of new and relevant information are provided ... The list of the 50 contributors is distinguished and with a compelling international representation ... chapters are thoroughly referenced ... Diagrams and tables are plentiful ... I thoroughly recommend this textbook to thoughtful microbiologists and medical scientists" from Aus. J. Med. Sci. (2015) 36: 89.

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