| Preface | |
| The Value of Models in Animal Cell Biotechnology | p. 1 |
| The Manzanar Project - A Unique Way to End World Hunger | p. 7 |
| Experience in Cell Line Testing | p. 9 |
| Virus Removal and Inactivation in Process Validation | p. 15 |
| Multilocus DNA Fingerprinting in the Analysis of Cell Stocks: Stability Studies and Application to a Wide Range of Species | p. 31 |
| Alteration of Cell Surface Glycoproteins through Differentiation from a Human Histiocytic Lymphoma Cell Line, U-937, to a Macrophage-Like Cell Line, U-M | p. 41 |
| Removability of Virus Particles and Permeability of Protein from Cell Culture Medium Using Cuprammonium Regenerated Cellulose Hollow Fiber (BMM) | p. 49 |
| An Evaluation of Hybridoma Cell-Specific Productivity: Perfused Immobilized, Continuous Suspension, and Batch Suspension Cultures | p. 57 |
| Dynamics of Aggregate Culture of Mammalian Cells | p. 65 |
| Effect of Protein Adsorption on Cell Attachment on Solid Surfaces | p. 71 |
| Characterization of Cell Growth and Improvement of Attachment Kinetics on Macroporous Microcarriers | p. 77 |
| Application of Three Dimensional Culture of Adult Rat Hepatocytes in Puf Pores for Artificial Liver Support System | p. 81 |
| Novel Validation Method of Virus-Removability for Biological Cell Culture Products Using Polymeric Membrane Filters | p. 87 |
| Selective Formation and Immobilization by Re-Attachment of Floating Spheroids of Rat Hepatocytes | p. 103 |
| Engineering of Ultrafiltration Hollow Fiber Bioreactors for Mammalian Cell Protein Production | p. 109 |
| Production of hEPO by Recombinant C127 Cells Using Hollow Fiber Culture System | p. 115 |
| Oscillatory Behavior in Continuous Aggregate Cultures of Mammalian Cells | p. 121 |
| Detection of Mammalian Cell Attachment and Lysis on a Metal Surface Using a Piezoelectric Sensor | p. 129 |
| Strategies for Economic GMP Production of Mammalian Cell Expressed Proteins | p. 135 |
| Use of Medium Concentrates to Improve Bioreactor Productivity | p. 143 |
| Separation of Animal Cells in Continuous Cell Culture Systems | p. 149 |
| An Automated System for Hollow Fiber Cell Culture | p. 155 |
| Automatic Selection System of Monoclonal Antibody Producing Cells | p. 165 |
| Continuous Monoclonal Antibody Production by a Composite Gel Perfusion Bioreactor in a Protein-Free Medium | p. 173 |
| High Density Cultivation of Hybridoma Cells by Using Permeable Capillaries | p. 179 |
| Recognition and Counting Method of Mammalian Cells on Microcarrier Using Image Processing and Neural Network | p. 185 |
| Mitochondrial Genome Transcription in Cultured Animal Cells | p. 193 |
| Large-Scale Mammalian Cell Cultures by Application of Macroporous Cellulose Carriers | p. 201 |
| High Density Perfusion Culture of Animal Cells Using a Novel Continuous Flow Centrifuge | p. 209 |
| Membrane Dialysis Bioreactor with Integrated Radial-Flow Fixed Bed - A New Concept for Continuous Cultivation of Animal Cells | p. 217 |
| Effect of Glutamine Supplementation on the Growth of Hybridoma Cells Cultivated in a Reactor Coupled with an Ammonia Removing System | p. 225 |
| Virus Containment Continuous Culture of Animal Cells | p. 233 |
| A Novel Bioreactor Process for Anchorage-Independent Animal Cells Immobilized within Porous Biomass Support Particles | p. 239 |
| Effects of Environmental Parameters on CHO Cell Growth in Batch and Chemostat Cultures and on Human IFN-[gamma] Synthesis and Fidelity | p. 245 |
| Design and Characterization of Electrically Controlled Bioreactor | p. 251 |
| Modulation of the Proliferation of Cultured Hepatoma Cells by Urea Cycle-Related Amino Acids | p. 257 |
| The Effects of Glutamine Concentration on Growth and Monoclonal Antibody Production in Fed-Batch Operation | p. 265 |
| Stimulation of Animal Cell Metabolism by Shear Stress | p. 271 |
| Effects of Conditioned Medium on the Growth Kinetics and the Monoclonal Antibody Productivity of Hybridoma Cells | p. 279 |
| Factors Influencing Expression and Post-Translational Modification of Recombinant Protein C | p. 287 |
| A Simple Automatic Control System of PH and DO | p. 295 |
| Hybridoma Culture in Iron-Rich Protein-Free Medium: Cell Growth, Apoptosis, and Nature of Macromolecules Recovered from the Culture Fluid | p. 303 |
| A Novel Vero Cell Line for Use as a Mammalian Host-Vector System in Serum-Free Culture | p. 311 |
| Serum Free Culture of Human-Human Hybridoma Secreting Monoclonal Antibodies against Stomach Cancer | p. 321 |
| Serum-Free Media for the Growth and Maintenance of the Differentiated State of Keratinocytes, Hepatocytes, and Neural Cells | p. 327 |
| Characterization of an Airway Epithelial Cell from Neonatal Rat | p. 335 |
| Production of Human Antithrombin-III in a Serum-Free Culture of CHO Cells | p. 345 |
| A Novel Protein- and Hormone-Free Medium: Its Application to Hybridoma Culture and Monoclonal Antibody Production | p. 353 |
| EDF (Erythroid Differentiation Factor = Activin A) Production in Recombinant CHO Cells | p. 361 |
| A Novel Serum Free Medium for Mouse Hybridomas and Human Lymphoblastoid Cell Lines | p. 369 |
| A Simple Structured Model Predicted Positively-, Negatively-, or Non-Growth Associated Antibody Production Rate Depending on Culture Conditions | p. 375 |
| Change in Monoclonal Antibody Productivity in Immobilized Hybridoma Cells at Low Dissolved Oxygen Concentrations | p. 383 |
| Improved Monoclonal Antibody Production of a Hybridoma by Varying the Oxygen Tension During a Suspension Culture | p. 391 |
| Enhancement of Productivity by Yield Improvements Using Simulation Techniques | p. 397 |
| Studies on the Production of Recombinant Human NF-IL6 in Mouse L Cell | p. 405 |
| Enhancing Effect of Interleukin-6 on Antibody Productivity of a Hybridoma Cell Line | p. 413 |
| Improved Production of Recombinant Proteins by the Baculovirus Expression System | p. 419 |
| Production and Product Integrity of Recombinant HIV-1 gag-Particles (p55) with the Baculovirus Expression System | p. 425 |
| Enhancement of Biological Productivity in Serum-Free Culture | p. 431 |
| Enhancement of IGM Production of HB4C5 Cells by Chitosan | p. 439 |
| Repression of Ovalbumin Gene Expression in the Chicken Oviduct Cell | p. 445 |
| Constitutive Long-Term Production of Recombinant Human Interferon-Gamma by Transformed Mouse C127 Cells Cultured in Serum Free Medium | p. 453 |
| Possible Involvement of Protein Tyrosine Sulfation in the Polarized Protein Targeting in Filter-Grown Madin-Darby Canine Kidney (MDCK) Cells | p. 463 |
| Protein Tyrosine Sulfation in Animal Cells and Its Simulation in Vitro in the Downstream Processing of Proteins | p. 473 |
| Expression of CARP [alpha]-Globin Gene in Tilapia Ovary Cells | p. 481 |
| Immunosuppressive Functions of Cells from Intestinal Tissues | p. 491 |
| Biological Functions of Carbohydrates in Erythropoietin | p. 499 |
| Cloning and Expression of Flatfish Interleukin 2 Gene | p. 509 |
| Serum-Free Mouse Embryo (SFME) Cells and Transforming Growth Factor (TGF)[beta]1 | p. 515 |
| Anti-Tetanus Human Monoclonal Antibodies-Comparative Studies on Their Protective Activity with Polyclonal Antibody | p. 521 |
| Production of Chicken Monoclonal Antibody | p. 527 |
| Generation and Characterization of Murine Anti-Human Transforming Growth Factor-[beta]1 Monoclonal Antibodies | p. 535 |
| Examination of Lung Cancer Using a Human Monoclonal Antibody HB4C5-Clone 3 | p. 541 |
| Alteration of Reactivity of Human Monoclonal Antibodies Produced by Concanavalin A-Resistant Hybridomas | p. 547 |
| Development of Mouse Fibroblast Dermal Equivalent Using Tissue Culture Technique | p. 553 |
| Effects of Some Food Additives and Mycotoxins on the Growth of HUH-6KK Cells | p. 559 |
| Europium-Linked Immuno Assay : Production of Immunoglobulin by Human-Human Hybridoma Cell Lines | p. 565 |
| The Protective Role of Polyphenols in Cytotoxicity of Hydrogen Peroxide | p. 571 |
| Author Index | p. 577 |
| Subject Index | p. 581 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
