| Preface | |
| Evaluation of viral safety of biotechnology products derived from cell lines of human or animal origin | p. 1 |
| Combination of virus removal and inactivation for optimization of recovery of protein | p. 9 |
| Strategy of virus removal/inactivation of plasma-derived products: Interest of nanofiltration as a new virus elimination method | p. 17 |
| Expression of the extracellular domain of the human growth hormone receptor gene by an insect-baculovirus system | p. 29 |
| Expression of recombinant receptors in insect cells | p. 35 |
| Production of a transmission blocking vaccine candidate of rodent malaria Plasmodium berghei using a baculovirus expression vector system | p. 41 |
| Establishment of human B cell lines producing antigen-specific antibodies through SCID mice reconstituted with human peripheral blood lymphocytes | p. 47 |
| Production of humanised monoclonal antibodies for in vivo imaging and therapy | p. 53 |
| Clinical results with humanized and human monoclonal antibodies | p. 63 |
| Clinical applications of human monoclonal antibodies | p. 75 |
| Autocrine regulation of milk protein secretion | p. 81 |
| Therapeutic application of transgenic animals | p. 87 |
| FDA perspective on the use of transgenic animals in the manufacture of therapeutic products intended for human use: Safety concerns | p. 95 |
| Hepatocyte spheroid: Differentiated features and potential utilization for the bioreactor of artificial liver support | p. 99 |
| Microencapsulated islets as a bioartificial pancreas | p. 103 |
| A novel three-dimensional long-term bone marrow bioreactor culture system | p. 115 |
| Process technology in cellular and tissue engineering | p. 121 |
| Fish IGF-I and IGF-II: Age-related and tissue-specific expression and transgenesis | p. 127 |
| Inhibition of aquatic birnavirus replication process in fish cells by viral antisense RNA | p. 137 |
| Functional analysis of the homology and heterology promoters in fish-cultured cells | p. 145 |
| Dialysis perfusion systems for the production and retention of high-valued products from animal cells | p. 151 |
| Methods for animal cell immobilization using electrostatic droplet generation | p. 157 |
| Using oxygen uptake rates to time infections in the baculovirus expression vector system | p. 161 |
| On-line monitoring and control of glucose, glutamine, lactate and ammonium during a high-cell-density cultivation of hybridoma cells | p. 167 |
| Cultivation of hybridomas, human cancer and human primary cells using the miniaturized hollow fibre bioreactor TECNOMOUSE | p. 171 |
| Electrically controlled production of monoclonal antibody by immobilized hybridoma | p. 177 |
| Effect of endogenous retrovirus production on hybridoma productivity | p. 183 |
| Effect of dissolved oxygen concentration on growth and production of biomaterials by animal cell culture | p. 191 |
| Enhanced productivity in insect cell culture by control of the chemical environment | p. 197 |
| Energy balance and protein synthesis in hybridoma culture | p. 205 |
| Application of fish cells immortalized by oncogenes - diagnostic method for the detection of fish iridovirus (Iridoviridae) by polymerase chain reaction | p. 213 |
| Enhancement of cellular productivity by oncogene transfection | p. 219 |
| Comparison of mutant [beta]-lactoglobulin production between mammalian cell and yeast | p. 225 |
| Enhancement of [gamma]-carboxylation of recombinant activated protein C by cell fusion | p. 231 |
| Modulation of oligosaccharide structure of a pro-urokinase derivative (pro-UK[Delta]GSI) by culture conditions | p. 237 |
| The analysis of antigen-antibody binding using anti-RNase A single chain Fv-3A21 | p. 243 |
| Enhanced transcriptional activity by modifying the chicken ovalbumin gene promoter in the oviduct cell of chickens | p. 249 |
| Expression of a foreign gene introduced into bovine embryos at early stages of development | p. 255 |
| Expression of milk protein-CAT chimeric genes in transfected bovine and mouse mammary epithelial cells | p. 259 |
| Differentiation and death of a small intestinal epithelial cell line, IEC-6 | p. 265 |
| Establishment and characterization of [alpha]s1-casein-specific T cell lines from milk-allergic patients | p. 273 |
| Action of branched-chain amino acids on protein degradation in cultured muscle cells | p. 279 |
| Immortalization of human endothelial cells by temperature sensitive simian virus 40 | p. 287 |
| Establishment of hepatoblastoma cell line, HUH-6KK for production of biochemicals | p. 293 |
| In vitro culture of primary B cells specific to a short peptide | p. 299 |
| Leukemia inhibitory factor and related peptides regulate glial fibrillary acidic protein in serum-free mouse embryo (SFME) cells | p. 305 |
| Factors affecting the induction of ovalbumin mRNA in primary cultures of oviductal cells in the chicken | p. 311 |
| Manipulation of chicken primordial germ cells for transgenic chicken | p. 317 |
| Anchorage-dependent growth and recombinant protein production by chinese hamster ovary cells in serum-free medium | p. 325 |
| High cell density and serum-free culture of hybridoma cells using fixed bed porosphere system | p. 331 |
| Replacement of bovine insulin with recombinant long R[superscript 3] IGF-1 in CHO cells | p. 337 |
| Serum-free medium for normal human melanocytes | p. 345 |
| Intracellular analysis of a lymphoblastoid cell line using H-NMR | p. 351 |
| Certified serum for productivity enhancement | p. 359 |
| Recombinant antibody expression in a fixed bed perfusion system | p. 365 |
| Cost effective high density mammalian cell culture | p. 373 |
| Continuous automated reconstitution of liquid media concentrates | p. 383 |
| Relationship of inactivation techniques of the sera to cellular attachment on phema and polypropylene surfaces | p. 389 |
| Establishment of a rat extracorporeal circulation system to estimate the performance of a hybrid artificial liver | p. 395 |
| Presumption of the concentration of several constituents in the culture broth of mouse - mouse hybridoma by near infrared reflectance spectroscopy | p. 401 |
| Enhancement of monoclonal antibody production related to metabolic behavior in high density hybridoma culture | p. 407 |
| High density culture of rCHO cells using hollow fiber systems | p. 413 |
| A hollow fiber bioreactor immobilizing hepatocyte spheroids rapidly formed by large-scale suspension culture | p. 417 |
| Effect of medium additives at AcNPV infection of insect cells on recombinant [beta]-galactosidase production in batch and two-stage bioreactor systems | p. 423 |
| On the enhancement of growth yields in hybridoma culture | p. 429 |
| Production of rG-CSF by CHO cell in aggregate microbeads culture | p. 435 |
| Perfusion culture using a macroporous microcarrier | p. 441 |
| High speed stirring culture using macroporous microcarrier | p. 447 |
| Cryopreservation of cell-laden collagen microspheres | p. 453 |
| A continuous cell centrifuge for lab scale perfusion processes of mammalian cells | p. 463 |
| Polystyrene microcarriers coated with a combination of adhesion-promoting peptides | p. 469 |
| Chicken whole-embryo culture as a quick and convenient system for searching physiologically active compounds | p. 475 |
| Effect of fruit components on the proliferation and antibody production of human-human hybridoma cell lines | p. 481 |
| Induction of HMG-CoA reductase and malic enzyme gene expressions by polychlorinated biphenyls in rat hepatocytes cultured on EHS-gel, not on Type I collagen | p. 487 |
| Effects of glycinin acidic A1a subunit on insulin-involved cellular metabolism in rat adipocytes and 3T3-L1 cells | p. 491 |
| Physiologically functional substances in shellfish toward several cultured mammalian cell lines | p. 497 |
| Purification and characterization of extracted abalone (Haliotis discus) bioactive protein | p. 503 |
| Development of artificial skin using raft culture technique and its application to study the mechanism of oncogenesis | p. 509 |
| The integrity test of virus removal membrane through gold particle method and liquid forward flow test method | p. 517 |
| Theoretical approach for integrity test of virus removal filter | p. 523 |
| "The FDA quality/compliance continuum... Where do cell culture and molecular biology products stand" | p. 529 |
| Removal of residual DNA in biological products by cuprammonium regenerated cellulose hollow fiber (BMM) | p. 537 |
| Removability and permeability of DNA in protein solution using BMM | p. 543 |
| Protective in vivo effect against murine rickettsia infection by recombinant myeloperoxidase produced in CHO cells | p. 549 |
| A novel anti-tumorigenic protein specific to SV40- and human papilloma virus-transformed cells -the possible action mechanism- | p. 555 |
| Suppressive lymphokines produced by CD8[superscript +] T cells | p. 561 |
| Characterization of erythropoietin receptor on two neuronal cell lines | p. 567 |
| Heterogeneity in light-chains of monoclonal antibodies produced by mouse hybridomas raised with NS-1 myelomas | p. 575 |
| Purification and characterization of two molecular forms of bovine complement factor H | p. 581 |
| Purification and characterization of growth and differentiation factors from human osteosarcoma cell line, OST-1-PF | p. 589 |
| Protection against Cowdria ruminantium infection in mice with gamma interferon produced in animal cells | p. 595 |
| A retrovirus-associated antigen expressed in human lung carcinoma | p. 601 |
| Author Index | p. 607 |
| Subject Index | p. 611 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
