Advances in Experimental Medicine and Biology

From the Molecular to Integrative Pharmacology

By: Michael E. Maragoudakis (Editor)

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Hardcover | 30 June 2000

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400 Pages

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26.04 x 17.15 x 3.18

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Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field.

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Non-Fiction Medicine Clinical & Internal Medicine Haematology Science Biology, Life Sciences Biochemistry Pre-Clinical Medicine & Basic Sciences Physiology Diseases & Disorders Oncology Other Branches of Medicine

Pharmacology Dermatology Ophthalmology

Introductory Comments	p. 1
Angiogenic Factors and Their Receptors
Examining New Models for the Study of Autocrine and Paracrine Mechanisms of Angiogenesis through FGF[subscript 2]-Transfected Endothelial and Tumour Cells	p. 7
Tie-1 Receptor Tyrosine Kinase Endodomain Interaction with SHP2: Potential Signalling Mechanisms and Roles in Angiogenesis	p. 35
On the Mechanism(s) of Thrombin Induced Angiogenesis	p. 47
Endothelial Receptor Tyrosine Kinases in Involved Blood Vessel Development and Tumor Angiogenesis	p. 57
Ontogeny of the Endothelial System in the Avian Model	p. 67
Regulation of Angiogenesis and Transduction Mechanisms Involved
The Role of Pericytes in Controlling Angiogenesis In Vivo	p. 81
Insights into the Vasodilation of Rat Retinal Vessels Evoked by Vascular Endothelial Growth Factor[subscript 121] (VEGF[subscript 121])	p. 101
Signal Transduction and Transcriptional Regulation of Angiogenesis	p. 109
Differential Contribution of Bradykinin Receptors in Angiogenesis	p. 117
Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Breakdown in VEGF Transgenic Mice	p. 129
Revascularization of Ischemic Tissues with SIKVAV and Neuropeptide Y (NPY)	p. 139
Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor, Protein S, in Vascular Cells	p. 155
Role of Extracellular Matrix and Adhesion Molecules in Angiogenesis
Targeting Integrins a[subscript v]b[subscript 3] and a[subscript v]b[subscript 5] for Blocking Tumor-Induced-Angiogenesis	p. 169
Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis with Synthetic Matrixin Inhibitors	p. 181
Inhibitors of Angiogenesis and Their Mechanisms of Action
Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by Inducing Apoptosis	p. 197
The Characterization of Angiogenesis Inhibitor from Shark Cartilage	p. 209
Quantitative Assays for the Chick Chorioallantoic Membrane	p. 225
Angiogenesis and Malignant Transformation
MYCN Oncogene and Angiogenesis: Down-Regulation of Endothelial Growth Inhibitors in Human Neuroblastoma Cell	p. 239
From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the Colorectal Adenoma - Carcinoma Model	p. 249
Tumor Angiogenesis, Macrophages, and Cytokines	p. 267
Microvessel Density, Thymidine Phosphorylase Expression, and Resistance of Head and Neck Cancer to Chemo-Radiotherapy	p. 285
Differential Expression of Angiogenic and of Vascular Survival Factors in Non-Small Cell Lung Cancer (NSCLC)	p. 291
Thymidine Phosphorylase Activity in Normal, Hyperplastic and Neoplastic Endometrium--Correlation with Intratumoral Angiogenesis	p. 297
Preclinical Developments of Angiogenesis Inhibitors
Inhibition of VEGF Signal Transduction	p. 307
Combretastatins: Novel Vascular Targeting Drugs for Improving Anti-Cancer Therapy	p. 311
Clinical Applications
Therapeutic Angiogenesis for Ischemic Heart Disease	p. 327
Abstracts of Posters	p. 351
Participants' Photo	p. 375
List of Participants	p. 377
Index	p. 381
Table of Contents provided by Syndetics. All Rights Reserved.

Advances in Experimental Medicine and Biology

From the Molecular to Integrative Pharmacology

At a Glance

Hardcover

Shipping

How to return your order

Defective items

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