An Introduction to Toxicogenomics

By: Michael E. Burczynski (Editor)

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Hardcover | 26 March 2003 | Edition Number 1

At a Glance

Hardcover
358 Pages

Dimensions(cm)
25.4 x 17.8 x 2.06

Hardcover

RRP $420.00

$359.75

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Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis.

Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies.

Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.

Industry Reviews

"... Burczynski has carefully constructed this volume to encompass background information and basic science through to applications and future uses. ... [This book] takes a complex, nascent science, reducing its complexity to details and discussions at the level of the ... readership."
- Veterinary Pathology, 42:1, 2005

"...a great text that explains the concepts underlying this new field to readers who will use these approaches in future research. It provides a comprehensive overview of this new discipline by focusing on toxicology. It's a good and needed guide to get into toxicogenomics in the right productive and accurate way."

- in Vet Human Toxicology

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