Agents and Actions Supplements

I. Behavioural Responses.- Characterising a kinesis response: Time averaged measures of cell speed and directional persistence.- Measurement of phenomenological parameters for leukocyte motility and chemotaxis.- Shape, motility and locomotor responses of neutrophil granulocytes.- Adhesion and the locomotion of neutrophils on surfaces and in matrices.- Contact guidance of locomotion of human leukocytes.- Adherence and regulation of leukotaxis.- Binding characteristics of the complement peptides C3a and C5a-desArg to cellulose nitrate filters in Boyden chambers.- Chemotaxis of tumor cells.- II. Mediators.- The role of leukotriene B4 as a mediator of leukocyte function.- On the biological role of lipid chemotactic factors.- Effects of bradykinin, some of its fragments, kallidin and various synthetic analogs on rat PMN chemotactic responsiveness.- Biological and chemical characterization of eosinophil chemotactic factors from human leukocytes.- Mediators and modulators of human lymphocyte chemotaxis.- In vitro and in vivo effects of anti-tumor antibody covalently coupled to a chemotactic peptide.- III. Receptors.- The C5a receptor of neutrophils and macrophages.- Cytotaxin receptors on human neutrophils: Modulation of C5a and peptide receptor number.- Dynamics of human neutrophil receptors for the chemoattractant fMet-Leu-Phe.- Cellular processing of the formyl peptide receptor.- Chemoattractant receptor affinity reflects its ability to transducer different biological responses.- IV. Transduction and Effector Mechanisms.- Some early ionic events in neutrophil activation by chemotactic factors.- Calcium movements and protein phosphorylation in chemotactically stimulated neutrophils.- The relationship between the transient cAMP peak and various leukocyte responses.- Exocytosis induced in neutrophils by chemotactic agents and other stimuli.- Lung injury secondary to chemotactic factor-induced leukocyte activation.- V. Abnormal Locomotion and Chemotaxis.- Clinical disorders of phagocyte locomotion.- The effect of the local anesthetic tetracaine on the migration of guinea pig granulocytes.- VI. E.L. Becker: Summary.- VII. Subject Index.