Advances in Genetics Volume 57

Volume 57

By: Jay Dunlap

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Hardcover | 9 March 2007

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320 Pages

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24.13 x 16.51 x 2.54

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The sequencing of several fungi genomes has spurred major advances in the field. Fungal genomics has been having a pivotal impact on applied research in agriculture, food sciences, natural resource management, pharmaceuticals, and biotechnology, as well as to basic studies in the life sciences. Fungal Genomics covers exciting new developments in this growth field, from genomic analysis to human fungal pathogen genomics, comparative genomics of fungi, and the genomics of fungal development.

Includes information on aspergillus genomes
Discusses sex and its role in virulence of human fungal pathogens
Covers the genomic analysis of neurospora

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Contributors	p. ix
Preface	p. xiii
Genetics of Morphogenesis and Pathogenic Development of Ustilago maydis	p. 1
Introduction	p. 3
Mating	p. 4
Dimorphism	p. 12
Cell Cycle and Cytoskeletal Regulation	p. 17
Pathogenesis	p. 21
Genome-Wide Approaches for the Study of U. maydis	p. 27
The Plant Side of the Disease Equation	p. 36
Conclusion	p. 38
References	p. 38
Enabling a Community to Dissect an Organism: Overview of the Neurospora Functional Genomics Project	p. 49
Introduction	p. 51
Project 1: Systematic Gene Knockouts	p. 56
Project 2: Genome Informatics and Functional Annotation Studies	p. 71
Project 3: Profiling Transcription in Neurospora	p. 78
Project 4: cDNA Libraries and the Generation of a High-Density SNP Map	p. 85
Conclusions	p. 93
References	p. 93
Genomics of the Plant Pathogenic Oomycete Phytophthora: Insights into Biology and Evolution	p. 97
Introduction	p. 98
Advances in Structural Genomics	p. 100
Organization of Phytophthora Genomes	p. 104
Other Genetic Elements	p. 114
Tools for Functional Genomics	p. 115
Selected Areas of Phytophthora Research	p. 118
Conclusions and Prospects	p. 131
References	p. 132
Sex and Virulence of Human Pathogenic Fungi	p. 143
The Predominant Human Pathogenic Fungi	p. 144
Sex in Fungal Pathogens: Cost Versus Benefit	p. 146
Mating-Type Loci Are the Sex-Determining Regions in Fungi	p. 148
Sex in Cryptococcus	p. 149
The Unusual Cryptococcus Mating-Type Locus	p. 153
Genome Sequencing Identified Mating-Type Locus in the "Asexual" C. albicans and Led to the Discovery of Mating	p. 153
Mating-Type Locus in A. fumigatus	p. 157
Mating-Type Loci in Other Human Pathogenic Fungi	p. 157
Population Genetic Studies in "Asexual" Fungi Reveal Evidence of Sex	p. 159
The Role of Sex in Pathogenesis	p. 162
Concluding Remarks	p. 165
References	p. 166
From Genes to Genomes: A New Paradigm for Studying Fungal Pathogenesis in Magnaporthe oryzae	p. 175
Introduction	p. 176
Attachment and Appressorium Morphogenesis	p. 177
Mechanisms of Penetration	p. 187
Invasive Growth and Host-Pathogen Interactions	p. 190
Genes and Genome Features	p. 195
Functional Genomics	p. 204
Concluding Remarks	p. 208
References	p. 209
Genetic and Genomic Dissection of the Cochliobolus heterostrophus Tox1 Locus Controlling Biosynthesis of the Polyketide Virulence Factor T-toxin	p. 219
Introduction	p. 220
Tools for Genetic Analysis	p. 228
C. heterostrophus and SCLB	p. 233
The Genetics of T-Toxin Production	p. 235
Genomic Analysis of the Tox1 Locus	p. 242
The PM-Toxin Gene Cluster	p. 247
Are Additional Tox Loci Involved in T-Toxin Production?	p. 249
Model for Biosynthesis of T-Toxin	p. 250
The Evolution of Polyketide-Mediated Fungal Specificity for T-Cytoplasm Corn	p. 252
Conclusions	p. 254
References	p. 255
Fungal Genomics: A Tool to Explore Central Metabolism of Aspergillus fumigatus and Its Role in Virulence	p. 263
Introduction	p. 264
Nutritional Auxotrophy and Fungal Genetics	p. 265
Regulation of Amino Acid Biosynthesis	p. 268
Regulation of Ambient pH Response	p. 272
Regulation of Nitrogen Response Pathways	p. 275
Regulation of Carbon Response Pathways	p. 277
Concluding Remarks	p. 281
References	p. 281
Index	p. 285
Table of Contents provided by Ingram. All Rights Reserved.

Advances in Genetics Volume 57

Volume 57

At a Glance

Hardcover

Shipping

How to return your order

Defective items

You Can Find This Book In

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