2-Cyanoamines

Versatile Intermediates for Carboxamide Linkage Formation and Nitrogen-Containing Cyclic Systems Construction

By: Bianca

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Paperback | 31 January 2025

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240 Pages

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Over 160 years after the first formation of Î±-aminonitrile documented, it still carries a huge attention among the organic and medicinal chemists and employed as a powerful synthetic tool for nitrogen based organic compounds [1 - 6]. It is a versatile bifunctional intermediate with an ideal combination of amine and nitrile functionality in same carbon. Î±-aminonitrile motif themselves have found to be in many complex bioactive natural products [7 - 9], at same time as a key intermediate to many biochemical pathways and late stage synthetic approaches [10 - 13]. This beneficial synthetic intermediate still carries a potential to provide a plenty of opportunities for the establishment of innovative and effective synthetic methodologies.

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