Structure and Function of Intrinsically Disordered Proteins

By: Peter Tompa, Alan Fersht

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eText | 18 November 2009 | Edition Number 1

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The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev