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Single-cell Sequencing and Methylation

Methods and Clinical Applications

By: Buwei Yu (Editor), Jiaqiang Zhang (Editor), Yiming Zeng (Editor), Li Li (Editor), Xiangdong Wang (Editor)

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eText | 19 September 2020 | Edition Number 1

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With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.