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Probability Models for DNA Sequence Evolution - Richard Durrett

Probability Models for DNA Sequence Evolution

By: Richard Durrett

eText | 15 December 2008 | Edition Number 2

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Our basic question is: Given a collection of DNA sequences, what underlying forces are responsible for the observed patterns of variability? To approach this question we introduce and analyze a number of probability models: the Wright-Fisher model, the coalescent, the infinite alleles model, and the infinite sites model. We study the complications that come from nonconstant population size, recombination, population subdivision, and three forms of natural selection: directional selection, balancing selection, and background selection. These theoretical results set the stage for the investigation of various statistical tests to detect departures from "neutral evolution". The final chapter studies the evolution of whole genomes by chromosomal inversions, reciprocal translocations, and genome duplication. Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies from the biology literature that illustrate the use of these results. This book is written for mathematicians and for biologists alike. We assume no previous knowledge of concepts from biology and only a basic knowledge of probability: a one semester undergraduate course and some familiarity with Markov chains and Poisson processes.
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Non-FictionMathematicsApplied MathematicsProbability & StatisticsMedicineMedicine in GeneralPublic Health & Preventive MedicineEpidemiology & Medical StatisticsScienceBiology, Life SciencesCellular BiologyLife Sciences in General
Genetics excluding MedicalEvolutionChemistryOrganic ChemistryBiochemistry

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Published: 6th December 2010

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