List of Contributors, ix
Introduction, xiv
Robert Knutzen
Abbreviations, xvi
Section 1: Overview
1 The Endocrine System, 3
Sylvia L. Asa and Shereen Ezzat
2 Signs and Symptoms of Pituitary Disease, 13
Physical Manifestations of Pituitary Disorders, 13
Eva Fernandez-Rodriguez, Ignacio Bernabeu, and Felipe F. Casanueva
Emotional Manifestations of Pituitary Disorders, 15
Eva N. Kassi, Gregory A. Kaltsas, and George P. Chrousos
Mental Health Aspects of Pituitary Disorders, 17
Valerie Golden
Section 2: Disorders
3 Acromegaly, 23
Shereen Ezzat
4 Secondary Adrenal Insuffi ciency, 32
Tobias Else and Richard J. Auchus
5 Adult Growth Hormone Deficiency, 47
T. Brooks Vaughan III, Kristen Owen Riley, and Lewis S. Blevins Jr.
6 Pituitary Carcinoma, 55
Sylvia L. Asa
7 Craniopharyngioma, 59
Jessica K. Devin
8 Cushing's Syndrome, 67
Lewis S. Blevins Jr.
9 Empty Sella Syndrome, 77
Michael C. Oh and Manish K. Aghi
10 Familial Pituitary Adenomas, 87
Laura C. Hernandez-Ramirez and Marta Korbonits
11 Follicle Stimulating Hormone and Luteinizing Hormone Secreting Tumors, 111
Bahram Khazai, Ronald S. Swerdloff, and Christina Wang
12 Hypopituitarism, 120
Klara J. Rosenquist and Ursula B. Kaiser
13 Clinically Nonfunctioning Pituitary Adenomas, 130
Brandon A. Miller, Adriana G. Ioachimescu, and Nelson M. Oyesiku
14 Prolactinoma, 138
Luis G. Sobrinho
15 Rathke's Cleft Cysts, 146
Seunggu J. Han, Arman Jahangiri, and Manish K. Aghi
16 Thyroid Hormone Deficiency, 153
Whitney W. Woodmansee
17 Thyroid Stimulating Hormone Secreting Tumor, 159
Andrea Lania, Luca Persani, and Paolo Beck-Peccoz
18 Pituitary Disorders - Specific Issues for Women, 167
Maria Fleseriu, Christine G. Yedinak, Jessica Brzana, and Shirley McCartney
19 Hypogonadism and Male Sexual Function, 179
Prasanth N. Surampudi, Christina Wang, and Ronald S. Swerdloff
20 Pituitary Disorders Specific to Children, 193
Kathryn Pade and Mitchell E. Geffner
Section 3: Diagnosing Pituitary Disorders
21 Physical Examination , 207
Laurence Katznelson
22 Pituitary Endocrine Function Testing , 213
Shereen Ezzat
Section 4: Treatment of Pituitary Disorders
23 Medical Management of Pituitary Adenomas , 227
Paolo Cappabianca, Daniel M. Prevedello, Michelangelo de Angelis, Andressa Bornschein, Leo F. S. Ditzel Filho, Domenico Solari, Ricardo L. Carrau, Felice Esposito, Danielle de Lara, Luigi M. Cavallo, and Annamaria Colao
24 Surgical Management of Pituitary Disorders , 243
Pure Endoscopic Transsphenoidal Surgery, 243
Gautam U. Mehta and John A. Jane Jr.
Open Transcranial Approaches to the Sella, 245
Ian F. Dunn
Endoscopic Skull Base Approaches, 247
Tong Yang and Theodore H. Schwartz
Transnasal Endoscope-Assisted Transsphenoidal Approach for Pituitary Tumors, 248
Huy T. Duong and Daniel F. Kelly
25 Stereotactic Radiosurgery for Pituitary Adenomas, 255
Brian J. Williams, Stephen J. Monteith, and Jason P. Sheehan
26 Hormone Replacement Therapy, 265
Growth Hormone Deficiency in Adults, 265
Joseph A. M. J. L. Janssen and Aart Jan van der Lely
Growth Hormone Deficiency in Children and Adolescents, 269
Alan D. Rogol
Pituitary Hormone Replacement in Women, 272
Adriana G. Ioachimescu
Section 5: Complications that Accompany Pituitary Disease
27 Complications of Pituitary Disease, 279
Cardiac Complications, 279
Ludovica F. S. Grasso, Alessia Cozzolino , and Annamaria Colao
Cognitive Dysfunction, 280
Krystallenia I. Alexandraki, Gregory A. Kaltsas, and George P. Chrousos
Diabetes Insipidus, 281
Marco Faustini-Fustini and Giorgio Frank
Headaches, 282
Paul B. Rizzoli
Obesity, 283
Andrea L. Utz
Osteoporosis, 284
Andrea L. Utz
Permanent Hormone Deficiency, 285
Andrea L. Utz
Visual Deficits Caused by Pituitary Tumors, 286
Sashank Prasad
Section 6: General Psychological and Psychosocial Effects
28 General Psychological and Psychosocial Effects of Pituitary Disorders, 293
Valerie Golden
Section 7: Long Term: What You and Your Patients Can Expect
29 Living with Pituitary Disease, 303
Jessica K. Devin
Section 8: Research and Clinical Trials
30 Research and Clinical Trials, 313
Brittany P. Sumerel and Anthony P. Heaney
Section 9: Resources
31 Fundamentals of Pituitary Pathology, 325
Sylvia L. Asa
Glossary, 333
Pejman Cohan
Index, 347
