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Phenotypes and Genotypes : The Search for Influential Genes - Florian Frommlet

Phenotypes and Genotypes

The Search for Influential Genes

By: Florian Frommlet, Ma?gorzata Bogdan, David Ramsey

eText | 12 February 2016

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This timely text presents a comprehensive guide to genetic association, a new and rapidly expanding field that aims to elucidate how our genetic code (genotypes) influences the traits we possess (phenotypes). The book provides a detailed review of methods of gene mapping used in association with experimental crosses, as well as genome-wide association studies. Emphasis is placed on model selection procedures for analyzing data from large-scale genome scans based on specifically designed modifications of the Bayesian information criterion. Features: presents a thorough introduction to the theoretical background to studies of genetic association (both genetic and statistical); reviews the latest advances in the field; illustrates the properties of methods for mapping quantitative trait loci using computer simulations and the analysis of real data; discusses open challenges; includes an extensive statistical appendix as a reference for those who are not totally familiar with the fundamentals of statistics.

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Non-FictionComputing & I.T.Computer ScienceScienceBiology, Life SciencesLife Sciences in GeneralMedicineMedicine in GeneralPublic Health & Preventive MedicineEpidemiology & Medical StatisticsMolecular BiologyMathematics
Probability & StatisticsScience in General

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