Molecular Diagnostics

I. Introduction and Methodology???? Quantivative PCR: an introduction Signal Amplification Methods in Molecular Diagnostics The Lab-on-a-Chip Approach for Molecular Diagnostics Nucleic Extraction and Amplification General Procedures ???????? II. Quality Assurance, Regulatory, and Ethical Issues???? Billing and Reimbursement for Molecular Diagnostics Molecular Pathology and Infectious Diseases Ethical Considerations in Molecular Diagnostics Quality Control, Assurance, Identification and Standards ???? III. Genetic Disease???? Molecular Testing for Cystic Fibrosis and CFTR-Related Conditions Carrier Testing for Neurogenetic Diseases Hemochromatosis Standards and Recommendations for Molecular Diagnostic Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia ???? IV. Cancer???? The Role of Micro-RNAs in Cancer Molecular Diagnostics in the Evaluation of Cancer: Modern Concepts and Overview Gene Expression Analysis for Tumor Profiling GEA for TP Molecular Diagnostics of Hematopoetic Malignancies ???? V. Infectious Diseases ???? Viruses Hepatic B and C Viruses Molecular Diagnosis of Cytomegalovirus Molecular Detection of Multiple Respiratory Viruses

Bacteria Molecular Methods for Identification and Characterization of Acinetobacter species Molecular Detection and Surveillance of Healthcare-Associated Infections Molecular Detection Of Group B Streptococcus Role of Molecular Techniques in the Epidemiologic Investigation Of Hospital-Acquired Infections Human Papilloma Virus and its Role in Cervical Carcinoma ???? VI. Specialized Applications of Molecular Testing???? Molecular HLA Typing Methods Used in Clinical Laboratories Identification through DNA analysis in criminal and family relatedness investigations.

VII. Pharmacogenetics???? Overview of Pharmacogenomics and Applications for the Modern Clinical Laboratory UDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and Hyperbilirubinemia Pharmacogenetics of P-450 Enzymes Pharmacogenomics of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine/Azathioprine Therapy