Mechanosensing and Mechanochemical Transduction in Extracellular Matrix

Cover -- Contents -- Foreword -- Preface -- Acknowledgments -- Chapter 1: Introduction to Mechanochemical Transduction in Tissues -- 1.1 Background -- 1.1.1 Significance -- 1.1.2 Background Definitions -- 1.2 Cell and ECM Macromolecular Structure -- 1.2.1 Cellular Components -- 1.2.2 Macromolecular Structure -- 1.3 Mineralized Versus Nonmineralized Tissues -- 1.4 Cell Cytoskeleton, Extracellular Matrix, and Mechanochemical Transduction -- 1.5 Internal Stresses in Tissues -- 1.5.1 Internal Stresses Acting within Cartilage -- 1.6 Mechanical Properties -- 1.7 Mechanochemical Transduction Processes -- 1.8 Scope of Book -- Suggested Reading -- Chapter 2: Macromolecular Structures in Tissues -- 2.1 Introduction -- 2.2 Protein Structure -- 2.2.1 Stereochemistry of Polypeptides -- 2.2.2 Primary and Secondary Structure -- 2.2.3 Supramolecular Structure -- 2.2.4 Examples of Other Proteins -- 2.2.5 Cell Attachment Factors -- 2.2.6 Integrins -- 2.2.7 Fibrinogen -- 2.2.8 Tubulin -- 2.3 Polysaccharides -- 2.3.1 Stereochemistry of Sugars -- 2.3.2 Stereochemistry of Polysaccharides -- 2.3.3 Structure of Glycosaminoglycans -- 2.4 Glycoprotein and Proteoglycan Structure -- 2.5 Stereochemistry of Lipids -- 2.6 Stereochemistry of Nucleic Acids -- 2.6.1 Primary and Secondary Structure of DNA and RNA -- 2.7 Relationship Between Higher-Order Structures and Mechanical Properties -- 2.8 Summary -- Suggested Reading -- Chapter 3: Microscopic and Macroscopic Structure of Tissues -- 3.1 Introduction -- 3.1.1 Generalized Approach to Tissue Structural Analyses -- 3.2 Structure of External and Internal Lining Tissues -- 3.2.1 Histology of Alveoli and Bronchus -- 3.2.2 Histology of Cornea -- 3.2.3 Oral Histology -- 3.2.4 Histology of Peritoneum and Pleura -- 3.2.5 Histology of Skin -- 3.2.6 Histology of Uterus -- 3.3 Conduit and Holding Structures -- 3.3.1 Structure of Blood Vessels and Lymphatics -- 3.3.2 Structure of Stomach and Intestines -- 3.3.3 Structure of Bladder and Ureter -- 3.4 Parenchymal or Organ-Supporting Structures -- 3.5 Skeletal Structures -- 3.5.1 Detailed Structure and Composition of Hyaline Cartilage -- 3.5.2 Detailed Structure and Composition Tendon, Ligament, and Joint Capsule -- 3.5.3 Detailed Structure of Mineralizing Tendon -- 3.6 Summary -- Suggested Reading -- Chapter 4: Determination of Physical Structure and Modeling -- 4.1 Introduction -- 4.2 Viscosity -- 4.2.1 What Is Viscosity? -- 4.2.2 Determination of the Shape Factor -- 4.2.3 Determination of Intrinsic Viscosity -- 4.2.4 Intrinsic Viscosity of Biological Macromolecules -- 4.3 Light Scattering -- 4.4 Quasi-Elastic Light Scattering -- 4.5 Ultracentrifugation -- 4.6 Electron Microscopy -- 4.7 Determination of Physical Parameters for Biological Macromolecules -- 4.8 Summary -- Suggested Reading -- Chapter 5: Self-Assembly of Biological Macromolecules -- 5.1 Introduction -- 5.2 Theory of Assembly of Biological Macromolecules.