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Voltage-Gated Calcium Channels : Molecular Biology Intelligence Unit - Gerald Werner Zamponi

Voltage-Gated Calcium Channels

Molecular Biology Intelligence Unit

By: Gerald Werner Zamponi (Editor)

Hardcover Published: 1st February 2005
ISBN: 9780306478406
Number Of Pages: 378

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Voltage Gated Calcium Channels is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the leading authorities in the calcium channel field with fresh perspectives from risings stars in the area, taking into account the most recent literature and concepts. This is the only all-encompassing calcium channel book currently available, and is an essential resource for academic researchers at all levels in the areas neuroscience, biophysics, and cardiovascular sciences, as well as to researchers in the drug discovery area.

Ca[superscript 2+] chemistry, storage and transport in biologic systems : an overviewp. 1
Monitoring intracellular Ca[superscript 2+] in brain slices with fluorescent indicatorsp. 12
A brief history of calcium channel discoveryp. 27
Biochemical studies of voltage-gated Ca[superscript 2+] channelsp. 48
Molecular properties of voltage-gated calcium channelsp. 61
Role of [beta] subunits in voltage-gated calcium channel functionsp. 95
Distribution and targeting mechanisms of voltage activated Ca[superscript 2+] channelsp. 113
The calcium channel and the transmitter release sitep. 141
Determinants of G protein inhibition of presynaptic calcium channelsp. 154
Phosphorylation-dependent regulation of voltage-gated Ca[superscript 2+] channelsp. 168
Ca[superscript 2+]-dependent modulation of voltage-gated Ca[superscript 2+] channelsp. 183
Voltage-dependent inactivation of voltage gated calcium channelsp. 194
Selective permeability of voltage-gated calcium channelsp. 205
The run-down phenomenon of Ca[superscript 2+] channelsp. 219
Calcium channels as therapeutic targetsp. 231
Calcium channelopathiesp. 240
The molecular basis of Ca[superscript 2+] antagonist drug action-recent developmentsp. 262
Calcium channel block and inactivation : insights from structure-activity studiesp. 281
Block of voltage-gated calcium channels by peptide toxinsp. 294
Calcium channels in the heartp. 309
Post-genomic insights into T-type calcium channel functions in neuronsp. 326
Voltage-gated Ca[superscript 2+] channels of the vertebrate retina : from the genetics of blindness to encoding the visual worldp. 334
Exploring the function and pharmacotherapeutic of potential voltage-gated Ca[superscript 2+] channels with gene-knockout modelsp. 346
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780306478406
ISBN-10: 0306478404
Series: Molecular Biology Intelligence Unit
Audience: Professional
Format: Hardcover
Language: English
Number Of Pages: 378
Published: 1st February 2005
Publisher: Springer Science+Business Media
Country of Publication: US
Dimensions (cm): 22.9 x 15.2  x 2.54
Weight (kg): 0.83