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Virtual Screening : An Alternative or Complement to High Throughput Screening :  An Alternative or Complement to High Throughput Screening - Gerhard Klebe

Virtual Screening : An Alternative or Complement to High Throughput Screening

An Alternative or Complement to High Throughput Screening

By: Gerhard Klebe (Editor)

Hardcover Published: November 2000
ISBN: 9780792366331
Number Of Pages: 295

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In the next couple of years the human genome will be fully sequenced. This will provide us with the sequence and overall function of all human genes as well as the complete genome for many micro-organisms. Subsequently it is hoped, by means of powerful bioinformatic tools, to determine the gene variants that contribute to various multifactorial diseases and genes that exist in certain infectious agents but not humans. As a consequence, this will allow us to define the most appropriate levels for drug intervention. It can be expected that the number of potential drug targets will increase, possibly by a factor of 10 or more. Nevertheless, sequencing the human genome or, for that matter, the genome of other species will only be the starting point for the understanding of their biological function. Structural genomics is a likely follow-up, combined with new techniques to validate the therapeutic relevance of such newly discovered targets. Accordingly, it can be expected that in the near future we will witness a substantial increase in novel putative targets for drugs. To address these new targets effectively, we require new approaches and innovative tools. At present, two alternative, yet complementary, techniques are employed: experimental high-throughput screening (HTS) of large compound libraries, increasingly provided by combinatorial chemistry, and computational methods for virtual screening and de novo design. As kind of status report on the maturity of virtual screening as a technique in drug design, the first workshop on new approaches in drug design and discovery was held in March 1999, at SchloƟ Rauischholzhausen, near Marburg in Germany. More than 80 scientists gathered and discussed their experience with the different techniques. The speakers were invited to summarize their contributions together with their impressions on the present applicability of their approach. Several of the speakers followed this request which is summarized in this publication.

Preface
Combination of molecular similarity measures using data fusionp. 1
Optimization of the drug-likeness of chemical librariesp. 17
Generating consistent sets of thermodynamic and structural data for analysis of protein-ligand interactionsp. 29
Multiple molecular superpositioning as an effective tool for virtual database screeningp. 43
A recursive algorithm for efficient combinatorial library dockingp. 63
Modifications of the scoring function in FlexX for virtual screening applicationsp. 83
A knowledge-based scoring function for protein-ligand interactions: Probing the reference statep. 99
Predicting binding modes, binding affinities and 'hot spots' for protein-ligand complexes using a knowledge-based scoring functionp. 115
Hydrophobicity maps and docking of molecular fragments with solvationp. 145
Virtual screening with solvation and ligand-induced complementarityp. 171
Similarity versus docking in 3D virtual screeningp. 191
Discovering high-affinity ligands from the computationally predicted structures and affinities of small molecules bound to a target: A virtual screening approachp. 209
In vitro and in silico affinity fingerprints: Finding similarities beyond structural classesp. 231
Computer-assisted synthesis and reaction planning in combinatorial chemistryp. 245
Evaluation of reactant-based and product-based approaches to the design of combinatorial librariesp. 265
Author Indexp. 289
Subject Indexp. 291
Table of Contents provided by Blackwell. All Rights Reserved.

ISBN: 9780792366331
ISBN-10: 0792366336
Audience: General
Format: Hardcover
Language: English
Number Of Pages: 295
Published: November 2000
Publisher: Springer
Country of Publication: NL
Dimensions (cm): 23.39 x 15.6  x 1.91
Weight (kg): 0.61

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